Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm

OBJECTIVE(S): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus), a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. To further...

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Detalles Bibliográficos
Autores principales: Hadjiasgary, Amirmasoud, Banafshe, Hamid Reza, Ardjmand, Abolfazl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366723/
https://www.ncbi.nlm.nih.gov/pubmed/25810886

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