Cargando…

Complex trait architecture: the pleiotropic model revisited

There is currently much debate about how much the genetic heritability of complex traits is due to very rare alleles. This issue is important because it determines sampling strategies for genetic association studies. Several recent theoretical papers based on a pleiotropic model for trait evolution...

Descripción completa

Detalles Bibliográficos
Autores principales:	North, T.-L., Beaumont, M. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366851/ https://www.ncbi.nlm.nih.gov/pubmed/25792462 http://dx.doi.org/10.1038/srep09351

Ejemplares similares

Incorporating pleiotropic quantitative trait loci in dissection of complex traits: seed yield in rapeseed as an example
por: Luo, Ziliang, et al.
Publicado: (2017)

Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematode Caenorhabditis remanei
por: O’Connor, Christine H, et al.
Publicado: (2021)

Genomic prediction of complex human traits: relatedness, trait architecture and predictive meta-models
por: Spiliopoulou, Athina, et al.
Publicado: (2015)

Bayesian reassessment of the epigenetic architecture of complex traits
por: Trejo Banos, Daniel, et al.
Publicado: (2020)

graph-GPA: A graphical model for prioritizing GWAS results and investigating pleiotropic architecture
por: Chung, Dongjun, et al.
Publicado: (2017)

Phenome-wide functional dissection of pleiotropic effects highlights key molecular pathways for human complex traits
por: Shikov, Anton E., et al.
Publicado: (2020)

Pleiotropic genetic architecture and novel loci for C-reactive protein levels
por: Koskeridis, Fotios, et al.
Publicado: (2022)

Pleiotropic Genetic Effects between Multiple Sclerosis and Musculoskeletal Traits
por: Jeong, Sohyun, et al.
Publicado: (2023)

Pleiotropic influence of DNA methylation QTLs on physiological and ageing traits
por: Mozhui, Khyobeni, et al.
Publicado: (2023)

Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
por: Bone, William P., et al.
Publicado: (2021)

Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence
por: Fu, Man Shun, et al.
Publicado: (2021)

Genetic architecture of complex traits and disease risk predictors
por: Yong, Soke Yuen, et al.
Publicado: (2020)

Pleiotropic Effects of Common and Rare GCKR Exonic Mutations on Cardiometabolic Traits
por: Yeh, Kuan-Hung, et al.
Publicado: (2022)

The Genetic Architecture of Ovariole Number in Drosophila melanogaster: Genes with Major, Quantitative, and Pleiotropic Effects
por: Lobell, Amanda S., et al.
Publicado: (2017)

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
por: Hormozdiari, Farhad, et al.
Publicado: (2018)

A Multilayer Interactome Network Constructed in a Forest Poplar Population Mediates the Pleiotropic Control of Complex Traits
por: Gong, Huiying, et al.
Publicado: (2021)

Author Correction: Bayesian reassessment of the epigenetic architecture of complex traits
por: Banos, Daniel Trejo, et al.
Publicado: (2020)

ShinyGPA: An interactive visualization toolkit for investigating pleiotropic architecture using GWAS datasets
por: Kortemeier, Emma, et al.
Publicado: (2018)

Separable neural mechanisms for the pleiotropic association of copy number variants with neuropsychiatric traits
por: Reinwald, Jonathan R., et al.
Publicado: (2020)

Detection of multiple quantitative trait loci and their pleiotropic effects in outbred pig populations
por: Nagamine, Yoshitaka, et al.
Publicado: (2009)

Epistasis and Natural Selection Shape the Mutational Architecture of Complex Traits
por: Jones, Adam G., et al.
Publicado: (2014)

Evaluation of an HMGA2 variant for pleiotropic effects on height and metabolic traits in ponies
por: Norton, Elaine M., et al.
Publicado: (2019)

The Next PAGE in Understanding Complex Traits: Design for the Analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study
por: Matise, Tara C., et al.
Publicado: (2011)

The Impact of Population Demography and Selection on the Genetic Architecture of Complex Traits
por: Lohmueller, Kirk E.
Publicado: (2014)

Complex genetic architecture underlying the plasticity of maize agronomic traits
por: Jin, Minliang, et al.
Publicado: (2023)

Stromal control of oncogenic traits expressed in response to overexpression of GLI2, a pleiotropic oncogene
por: Snijders, Antoine M., et al.
Publicado: (2008)

Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits
por: Grotzinger, Andrew D., et al.
Publicado: (2019)

Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci
por: Bellomo, Tiffany R., et al.
Publicado: (2022)

Two Novel AP2/EREBP Transcription Factor Genes TaPARG Have Pleiotropic Functions on Plant Architecture and Yield-Related Traits in Common Wheat
por: Li, Bo, et al.
Publicado: (2016)

A 2-step strategy for detecting pleiotropic effects on multiple longitudinal traits
por: Wang, Weiqiang, et al.
Publicado: (2014)

The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction and related behavioral traits
por: Antón-Galindo, Ester, et al.
Publicado: (2023)

Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits
por: Patxot, Marion, et al.
Publicado: (2021)

A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease
por: Sethi, Siddharth, et al.
Publicado: (2020)

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits
por: Diogo, Dorothée, et al.
Publicado: (2015)

A scalable variational approach to characterize pleiotropic components across thousands of human diseases and complex traits using GWAS summary statistics
por: Zhang, Zixuan, et al.
Publicado: (2023)

Pleiotropic Genes Affecting Carcass Traits in Bos indicus (Nellore) Cattle Are Modulators of Growth
por: G. T. Pereira, Anirene, et al.
Publicado: (2016)

Time‐specific and pleiotropic quantitative trait loci coordinately modulate stem growth in Populus
por: Du, Qingzhang, et al.
Publicado: (2018)

Novel genomic approaches unravel genetic architecture of complex traits in apple
por: Kumar, Satish, et al.
Publicado: (2013)

Fine Mapping and Candidate Gene Prediction of a Pleiotropic Quantitative Trait Locus for Yield-Related Trait in Zea mays
por: Liu, Ruixiang, et al.
Publicado: (2012)

Comparing GWAS Results of Complex Traits Using Full Genetic Model and Additive Models for Revealing Genetic Architecture
por: Monir, Md. Mamun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tpd2f372i1noutobrn9d14292e