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Antioxidant and protective effects of Phytocee(™) against carbon tetrachloride-induced oxidative stress

BACKGROUND: This study evaluated the antioxidant potential of a polyherbal formulation (Phytocee(™)) in the rodent model. MATERIALS AND METHODS: Four groups of rats (n = 6) were pretreated with Vitamin C (20 mg/kg) or Phytocee(™) (20, 100, and 200 mg/kg), respectively for 10 days. Oxidative stress i...

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Detalles Bibliográficos
Autores principales: Joseph, Joshua Allan, Radhakrishnan, Uma, Mutyala, Sridhar, Goudar, Krishnagouda Shankargouda, Ayyappan, Usha Parackal Thachappully, Agarwal, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367033/
https://www.ncbi.nlm.nih.gov/pubmed/25810658
http://dx.doi.org/10.4103/0976-9668.149119
Descripción
Sumario:BACKGROUND: This study evaluated the antioxidant potential of a polyherbal formulation (Phytocee(™)) in the rodent model. MATERIALS AND METHODS: Four groups of rats (n = 6) were pretreated with Vitamin C (20 mg/kg) or Phytocee(™) (20, 100, and 200 mg/kg), respectively for 10 days. Oxidative stress in rat liver was induced by administration of carbon tetrachloride (CCl(4)) at 2 ml/kg as a single dose orally to all groups except the vehicle control group. After 24 h of administration of CCl(4), hepatic levels of malondialdehyde (MDA), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) levels were evaluated. RESULTS: Phytocee(™) administered groups at all the dose levels significantly reduced the hepatic MDA, serum ALT and AST levels with a marked increase in hepatic SOD and catalase as compared with CCl(4) treated group. CONCLUSION: The findings suggest that Phytocee(™) markedly reversed the effects of CCl(4) induced oxidative stress and can be used as an antioxidant feed supplement.