Cargando…

Utility of Transmission Electron Microscopy in Small Round Cell Tumors

Small round cell tumors (SRCTs) are a heterogeneous group of neoplasms composed of small, primitive, and undifferentiated cells sharing similar histology under light microscopy. SRCTs include Ewing sarcoma/peripheral neuroectodermal tumor family tumors, neuroblastoma, desmoplastic SRCT, rhabdomyosar...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Na Rae, Ha, Seung Yeon, Cho, Hyun Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and the Korean Society for Cytopathology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367119/
https://www.ncbi.nlm.nih.gov/pubmed/25812730
http://dx.doi.org/10.4132/jptm.2015.01.30
_version_ 1782362488960974848
author Kim, Na Rae
Ha, Seung Yeon
Cho, Hyun Yee
author_facet Kim, Na Rae
Ha, Seung Yeon
Cho, Hyun Yee
author_sort Kim, Na Rae
collection PubMed
description Small round cell tumors (SRCTs) are a heterogeneous group of neoplasms composed of small, primitive, and undifferentiated cells sharing similar histology under light microscopy. SRCTs include Ewing sarcoma/peripheral neuroectodermal tumor family tumors, neuroblastoma, desmoplastic SRCT, rhabdomyosarcoma, poorly differentiated round cell synovial sarcoma, mesenchymal chondrosarcoma, small cell osteosarcoma, small cell malignant peripheral nerve sheath tumor, and small cell schwannoma. Non-Hodgkin’s malignant lymphoma, myeloid sarcoma, malignant melanoma, and gastrointestinal stromal tumor may also present as SRCT. The current shift towards immunohistochemistry and cytogenetic molecular techniques for SRCT may be inappropriate because of antigenic overlapping or inconclusive molecular results due to the lack of differentiation of primitive cells and unavailable genetic service or limited moleculocytogenetic experience. Although usage has declined, electron microscopy (EM) remains very useful and shows salient features for the diagnosis of SRCTs. Although EM is not always required, it provides reliability and validity in the diagnosis of SRCT. Here, the ultrastructural characteristics of SRCTs are reviewed and we suggest that EM would be utilized as one of the reliable modalities for the diagnosis of undifferentiated and poorly differentiated SRCTs.
format Online
Article
Text
id pubmed-4367119
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher The Korean Society of Pathologists and the Korean Society for Cytopathology
record_format MEDLINE/PubMed
spelling pubmed-43671192015-03-20 Utility of Transmission Electron Microscopy in Small Round Cell Tumors Kim, Na Rae Ha, Seung Yeon Cho, Hyun Yee J Pathol Transl Med Review Small round cell tumors (SRCTs) are a heterogeneous group of neoplasms composed of small, primitive, and undifferentiated cells sharing similar histology under light microscopy. SRCTs include Ewing sarcoma/peripheral neuroectodermal tumor family tumors, neuroblastoma, desmoplastic SRCT, rhabdomyosarcoma, poorly differentiated round cell synovial sarcoma, mesenchymal chondrosarcoma, small cell osteosarcoma, small cell malignant peripheral nerve sheath tumor, and small cell schwannoma. Non-Hodgkin’s malignant lymphoma, myeloid sarcoma, malignant melanoma, and gastrointestinal stromal tumor may also present as SRCT. The current shift towards immunohistochemistry and cytogenetic molecular techniques for SRCT may be inappropriate because of antigenic overlapping or inconclusive molecular results due to the lack of differentiation of primitive cells and unavailable genetic service or limited moleculocytogenetic experience. Although usage has declined, electron microscopy (EM) remains very useful and shows salient features for the diagnosis of SRCTs. Although EM is not always required, it provides reliability and validity in the diagnosis of SRCT. Here, the ultrastructural characteristics of SRCTs are reviewed and we suggest that EM would be utilized as one of the reliable modalities for the diagnosis of undifferentiated and poorly differentiated SRCTs. The Korean Society of Pathologists and the Korean Society for Cytopathology 2015-03 2015-03-12 /pmc/articles/PMC4367119/ /pubmed/25812730 http://dx.doi.org/10.4132/jptm.2015.01.30 Text en © The Korean Society of Pathologists and the Korean Society for Cytopathology. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kim, Na Rae
Ha, Seung Yeon
Cho, Hyun Yee
Utility of Transmission Electron Microscopy in Small Round Cell Tumors
title Utility of Transmission Electron Microscopy in Small Round Cell Tumors
title_full Utility of Transmission Electron Microscopy in Small Round Cell Tumors
title_fullStr Utility of Transmission Electron Microscopy in Small Round Cell Tumors
title_full_unstemmed Utility of Transmission Electron Microscopy in Small Round Cell Tumors
title_short Utility of Transmission Electron Microscopy in Small Round Cell Tumors
title_sort utility of transmission electron microscopy in small round cell tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367119/
https://www.ncbi.nlm.nih.gov/pubmed/25812730
http://dx.doi.org/10.4132/jptm.2015.01.30
work_keys_str_mv AT kimnarae utilityoftransmissionelectronmicroscopyinsmallroundcelltumors
AT haseungyeon utilityoftransmissionelectronmicroscopyinsmallroundcelltumors
AT chohyunyee utilityoftransmissionelectronmicroscopyinsmallroundcelltumors