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Utility of Transmission Electron Microscopy in Small Round Cell Tumors
Small round cell tumors (SRCTs) are a heterogeneous group of neoplasms composed of small, primitive, and undifferentiated cells sharing similar histology under light microscopy. SRCTs include Ewing sarcoma/peripheral neuroectodermal tumor family tumors, neuroblastoma, desmoplastic SRCT, rhabdomyosar...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pathologists and the Korean Society for Cytopathology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367119/ https://www.ncbi.nlm.nih.gov/pubmed/25812730 http://dx.doi.org/10.4132/jptm.2015.01.30 |
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author | Kim, Na Rae Ha, Seung Yeon Cho, Hyun Yee |
author_facet | Kim, Na Rae Ha, Seung Yeon Cho, Hyun Yee |
author_sort | Kim, Na Rae |
collection | PubMed |
description | Small round cell tumors (SRCTs) are a heterogeneous group of neoplasms composed of small, primitive, and undifferentiated cells sharing similar histology under light microscopy. SRCTs include Ewing sarcoma/peripheral neuroectodermal tumor family tumors, neuroblastoma, desmoplastic SRCT, rhabdomyosarcoma, poorly differentiated round cell synovial sarcoma, mesenchymal chondrosarcoma, small cell osteosarcoma, small cell malignant peripheral nerve sheath tumor, and small cell schwannoma. Non-Hodgkin’s malignant lymphoma, myeloid sarcoma, malignant melanoma, and gastrointestinal stromal tumor may also present as SRCT. The current shift towards immunohistochemistry and cytogenetic molecular techniques for SRCT may be inappropriate because of antigenic overlapping or inconclusive molecular results due to the lack of differentiation of primitive cells and unavailable genetic service or limited moleculocytogenetic experience. Although usage has declined, electron microscopy (EM) remains very useful and shows salient features for the diagnosis of SRCTs. Although EM is not always required, it provides reliability and validity in the diagnosis of SRCT. Here, the ultrastructural characteristics of SRCTs are reviewed and we suggest that EM would be utilized as one of the reliable modalities for the diagnosis of undifferentiated and poorly differentiated SRCTs. |
format | Online Article Text |
id | pubmed-4367119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Society of Pathologists and the Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-43671192015-03-20 Utility of Transmission Electron Microscopy in Small Round Cell Tumors Kim, Na Rae Ha, Seung Yeon Cho, Hyun Yee J Pathol Transl Med Review Small round cell tumors (SRCTs) are a heterogeneous group of neoplasms composed of small, primitive, and undifferentiated cells sharing similar histology under light microscopy. SRCTs include Ewing sarcoma/peripheral neuroectodermal tumor family tumors, neuroblastoma, desmoplastic SRCT, rhabdomyosarcoma, poorly differentiated round cell synovial sarcoma, mesenchymal chondrosarcoma, small cell osteosarcoma, small cell malignant peripheral nerve sheath tumor, and small cell schwannoma. Non-Hodgkin’s malignant lymphoma, myeloid sarcoma, malignant melanoma, and gastrointestinal stromal tumor may also present as SRCT. The current shift towards immunohistochemistry and cytogenetic molecular techniques for SRCT may be inappropriate because of antigenic overlapping or inconclusive molecular results due to the lack of differentiation of primitive cells and unavailable genetic service or limited moleculocytogenetic experience. Although usage has declined, electron microscopy (EM) remains very useful and shows salient features for the diagnosis of SRCTs. Although EM is not always required, it provides reliability and validity in the diagnosis of SRCT. Here, the ultrastructural characteristics of SRCTs are reviewed and we suggest that EM would be utilized as one of the reliable modalities for the diagnosis of undifferentiated and poorly differentiated SRCTs. The Korean Society of Pathologists and the Korean Society for Cytopathology 2015-03 2015-03-12 /pmc/articles/PMC4367119/ /pubmed/25812730 http://dx.doi.org/10.4132/jptm.2015.01.30 Text en © The Korean Society of Pathologists and the Korean Society for Cytopathology. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kim, Na Rae Ha, Seung Yeon Cho, Hyun Yee Utility of Transmission Electron Microscopy in Small Round Cell Tumors |
title | Utility of Transmission Electron Microscopy in Small Round Cell Tumors |
title_full | Utility of Transmission Electron Microscopy in Small Round Cell Tumors |
title_fullStr | Utility of Transmission Electron Microscopy in Small Round Cell Tumors |
title_full_unstemmed | Utility of Transmission Electron Microscopy in Small Round Cell Tumors |
title_short | Utility of Transmission Electron Microscopy in Small Round Cell Tumors |
title_sort | utility of transmission electron microscopy in small round cell tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367119/ https://www.ncbi.nlm.nih.gov/pubmed/25812730 http://dx.doi.org/10.4132/jptm.2015.01.30 |
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