Hsp90 Inhibitor Can Inhibit UV-Carcinogenesis

Extensive exposure to solar ultraviolet radiation (UVR) is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90)...

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Autor principal: Katiyar, Santosh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367190/
https://www.ncbi.nlm.nih.gov/pubmed/25785948
http://dx.doi.org/10.1038/jid.2014.504
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author Katiyar, Santosh K.
author_facet Katiyar, Santosh K.
author_sort Katiyar, Santosh K.
collection PubMed
description Extensive exposure to solar ultraviolet radiation (UVR) is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90) inhibitor, prevents UVR-induced squamous cell carcinomas (SCC) in mice. The inhibitory effect of 17AAG on SCC was associated with the inhibition of the UVR-induced: (i) hyperplastic response, (ii) Hsp90β-PKCε interaction, and (iii) pStat3 and pAkt expression in mouse skin.
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spelling pubmed-43671902015-10-01 Hsp90 Inhibitor Can Inhibit UV-Carcinogenesis Katiyar, Santosh K. J Invest Dermatol Article Extensive exposure to solar ultraviolet radiation (UVR) is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90) inhibitor, prevents UVR-induced squamous cell carcinomas (SCC) in mice. The inhibitory effect of 17AAG on SCC was associated with the inhibition of the UVR-induced: (i) hyperplastic response, (ii) Hsp90β-PKCε interaction, and (iii) pStat3 and pAkt expression in mouse skin. 2015-04 /pmc/articles/PMC4367190/ /pubmed/25785948 http://dx.doi.org/10.1038/jid.2014.504 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Katiyar, Santosh K.
Hsp90 Inhibitor Can Inhibit UV-Carcinogenesis
title Hsp90 Inhibitor Can Inhibit UV-Carcinogenesis
title_full Hsp90 Inhibitor Can Inhibit UV-Carcinogenesis
title_fullStr Hsp90 Inhibitor Can Inhibit UV-Carcinogenesis
title_full_unstemmed Hsp90 Inhibitor Can Inhibit UV-Carcinogenesis
title_short Hsp90 Inhibitor Can Inhibit UV-Carcinogenesis
title_sort hsp90 inhibitor can inhibit uv-carcinogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367190/
https://www.ncbi.nlm.nih.gov/pubmed/25785948
http://dx.doi.org/10.1038/jid.2014.504
work_keys_str_mv AT katiyarsantoshk hsp90inhibitorcaninhibituvcarcinogenesis

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