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The σ1 Receptor Engages the Redox-Regulated HINT1 Protein to Bring Opioid Analgesia Under NMDA Receptor Negative Control

Aims: The in vivo pharmacology of the sigma 1 receptor (σ1R) is certainly complex; however, σ1R antagonists are of therapeutic interest, because they enhance mu-opioid receptor (MOR)-mediated antinociception and reduce neuropathic pain. Thus, we investigated whether the σ1R is involved in the negati...

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Detalles Bibliográficos
Autores principales:	Rodríguez-Muñoz, María, Sánchez-Blázquez, Pilar, Herrero-Labrador, Raquel, Martínez-Murillo, Ricardo, Merlos, Manuel, Vela, José Miguel, Garzón, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2015
Materias:	Original Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367239/ https://www.ncbi.nlm.nih.gov/pubmed/25557043 http://dx.doi.org/10.1089/ars.2014.5993

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