Receptor Tyrosine Kinase EphA5 Is a Functional Molecular Target in Human Lung Cancer

Lung cancer is often refractory to radiotherapy, but molecular mechanisms of tumor resistance remain poorly defined. Here we show that the receptor tyrosine kinase EphA5 is specifically overexpressed in lung cancer and is involved in regulating cellular responses to genotoxic insult. In the absence...

Descripción completa

Detalles Bibliográficos
Autores principales: Staquicini, Fernanda I., Qian, Ming D., Salameh, Ahmad, Dobroff, Andrey S., Edwards, Julianna K., Cimino, Daniel F., Moeller, Benjamin J., Kelly, Patrick, Nunez, Maria I., Tang, Ximing, Liu, Diane D., Lee, J. Jack, Hong, Waun Ki, Ferrara, Fortunato, Bradbury, Andrew R. M., Lobb, Roy R., Edelman, Martin J., Sidman, Richard L., Wistuba, Ignacio I., Arap, Wadih, Pasqualini, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367244/
https://www.ncbi.nlm.nih.gov/pubmed/25623065
http://dx.doi.org/10.1074/jbc.M114.630525

Ejemplares similares

Ejemplares similares