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Probing the Acceptor Active Site Organization of the Human Recombinant β1,4-Galactosyltransferase 7 and Design of Xyloside-based Inhibitors

Among glycosaminoglycan (GAG) biosynthetic enzymes, the human β1,4-galactosyltransferase 7 (hβ4GalT7) is characterized by its unique capacity to take over xyloside derivatives linked to a hydrophobic aglycone as substrates and/or inhibitors. This glycosyltransferase is thus a prime target for the de...

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Detalles Bibliográficos
Autores principales:	Saliba, Mineem, Ramalanjaona, Nick, Gulberti, Sandrine, Bertin-Jung, Isabelle, Thomas, Aline, Dahbi, Samir, Lopin-Bon, Chrystel, Jacquinet, Jean-Claude, Breton, Christelle, Ouzzine, Mohamed, Fournel-Gigleux, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Glycobiology and Extracellular Matrices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367269/ https://www.ncbi.nlm.nih.gov/pubmed/25568325 http://dx.doi.org/10.1074/jbc.M114.628123

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