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Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats
BACKGROUND: Exercise is a non-pharmacologic agent widely used for hypertension control, where low intensity is often associated with blood pressure reduction. Maximal lactate steady state (MLSS) was recently identified in spontaneously hypertensive rats (SHRs) as an important step in establishing se...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367833/ https://www.ncbi.nlm.nih.gov/pubmed/25888441 http://dx.doi.org/10.1186/s12899-015-0015-7 |
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author | Petriz, Bernardo A Almeida, Jeeser A Gomes, Clarissa P C Ernesto, Carlos Pereira, Rinaldo W Franco, Octavio L |
author_facet | Petriz, Bernardo A Almeida, Jeeser A Gomes, Clarissa P C Ernesto, Carlos Pereira, Rinaldo W Franco, Octavio L |
author_sort | Petriz, Bernardo A |
collection | PubMed |
description | BACKGROUND: Exercise is a non-pharmacologic agent widely used for hypertension control, where low intensity is often associated with blood pressure reduction. Maximal lactate steady state (MLSS) was recently identified in spontaneously hypertensive rats (SHRs) as an important step in establishing secure intensities for prescribing exercise for hypertensive phenotypes. Here we verified the effects of training around MLSS, 20% below MLSS, and 15% above MLSS on aerobic fitness and blood pressure status of SHR. Eighteen-week-old SHRs (n = 5, ~ 172.4 ± 8.1 mm Hg systolic blood pressure) were trained on a treadmill for 4 weeks for 30 min/day, 5 days/week at a velocity of 20 m.min(−1). After training, a novel MLSS and incremental test was performed to evaluate the animals’ aerobic fitness. Furthermore, ~ 22-week-old SHRs (n = 12, ~169.8 ± 13.8 mm Hg systolic blood pressure) were divided into non-exercised (CG, n = 4), low intensity (LIG, n = 4) and high intensity (HIG, n = 4) groups, where rats were trained at 16 m.min(−1) and 23 m.min(−1) respectively for 30 min/day, 5 days/week for 4 weeks. RESULTS: Exercise performed at MLSS enhanced aerobic fitness, leading to a novel MLSS, identified around 30 m.min(−1). Low and high intensity training reduced systolic blood pressure and only high intensity training led to improved aerobic fitness (28.1%, p < 0.01). CONCLUSIONS: Therefore, our data indicate a decrease in blood pressure due to low and high exercise intensity, and an increase in aerobic fitness provided by high-intensity exercise in SHRs. |
format | Online Article Text |
id | pubmed-4367833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43678332015-03-21 Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats Petriz, Bernardo A Almeida, Jeeser A Gomes, Clarissa P C Ernesto, Carlos Pereira, Rinaldo W Franco, Octavio L BMC Physiol Research Article BACKGROUND: Exercise is a non-pharmacologic agent widely used for hypertension control, where low intensity is often associated with blood pressure reduction. Maximal lactate steady state (MLSS) was recently identified in spontaneously hypertensive rats (SHRs) as an important step in establishing secure intensities for prescribing exercise for hypertensive phenotypes. Here we verified the effects of training around MLSS, 20% below MLSS, and 15% above MLSS on aerobic fitness and blood pressure status of SHR. Eighteen-week-old SHRs (n = 5, ~ 172.4 ± 8.1 mm Hg systolic blood pressure) were trained on a treadmill for 4 weeks for 30 min/day, 5 days/week at a velocity of 20 m.min(−1). After training, a novel MLSS and incremental test was performed to evaluate the animals’ aerobic fitness. Furthermore, ~ 22-week-old SHRs (n = 12, ~169.8 ± 13.8 mm Hg systolic blood pressure) were divided into non-exercised (CG, n = 4), low intensity (LIG, n = 4) and high intensity (HIG, n = 4) groups, where rats were trained at 16 m.min(−1) and 23 m.min(−1) respectively for 30 min/day, 5 days/week for 4 weeks. RESULTS: Exercise performed at MLSS enhanced aerobic fitness, leading to a novel MLSS, identified around 30 m.min(−1). Low and high intensity training reduced systolic blood pressure and only high intensity training led to improved aerobic fitness (28.1%, p < 0.01). CONCLUSIONS: Therefore, our data indicate a decrease in blood pressure due to low and high exercise intensity, and an increase in aerobic fitness provided by high-intensity exercise in SHRs. BioMed Central 2015-03-14 /pmc/articles/PMC4367833/ /pubmed/25888441 http://dx.doi.org/10.1186/s12899-015-0015-7 Text en © Petriz et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Petriz, Bernardo A Almeida, Jeeser A Gomes, Clarissa P C Ernesto, Carlos Pereira, Rinaldo W Franco, Octavio L Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats |
title | Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats |
title_full | Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats |
title_fullStr | Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats |
title_full_unstemmed | Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats |
title_short | Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats |
title_sort | exercise performed around mlss decreases systolic blood pressure and increases aerobic fitness in hypertensive rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367833/ https://www.ncbi.nlm.nih.gov/pubmed/25888441 http://dx.doi.org/10.1186/s12899-015-0015-7 |
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