Cargando…
Synchronous cardiac arrest in monozygotic twins with hypertrophic cardiomyopathy - Is sudden cardiac death genetically pre-programmed?
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a myocardial disorder characterised by left ventricular hypertrophy (LVH) in the absence of another cardiac or systemic disease capable of producing the magnitude of LVH evident. HCM causes variable symptoms and is one of the leading causes of sudden...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367866/ https://www.ncbi.nlm.nih.gov/pubmed/25885451 http://dx.doi.org/10.1186/s12872-015-0007-3 |
_version_ | 1782362555651457024 |
---|---|
author | Goh, Cheng Yee ul Haq, Muhammad Asrar Mutha, Vivek van Gaal, William J |
author_facet | Goh, Cheng Yee ul Haq, Muhammad Asrar Mutha, Vivek van Gaal, William J |
author_sort | Goh, Cheng Yee |
collection | PubMed |
description | BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a myocardial disorder characterised by left ventricular hypertrophy (LVH) in the absence of another cardiac or systemic disease capable of producing the magnitude of LVH evident. HCM causes variable symptoms and is one of the leading causes of sudden cardiac death (SCD) in young adults. While various phenotypic features of HCM among monozygotic twin pairs are not uncommonly reported, occurrence of synchronous cardiac arrest among them is not known from literature. CASE PRESENTATION: We present a case of monozygotic twins with HCM who both had a cardiac arrest post physical exertion in 63(rd) year of their lives. CONCLUSION: This case highlights potential genetics predisposition of cardiac arrest in patients with HCM despite having different phenotypic expression. SCD may be the only manifestation of patients with HCM. Decision of implantable cardioverter-defibrillator (ICD) placement for primary prevention of SCD should be based on the recommended guidelines, clinical judgment and patient’s preference. |
format | Online Article Text |
id | pubmed-4367866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43678662015-03-21 Synchronous cardiac arrest in monozygotic twins with hypertrophic cardiomyopathy - Is sudden cardiac death genetically pre-programmed? Goh, Cheng Yee ul Haq, Muhammad Asrar Mutha, Vivek van Gaal, William J BMC Cardiovasc Disord Case Report BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a myocardial disorder characterised by left ventricular hypertrophy (LVH) in the absence of another cardiac or systemic disease capable of producing the magnitude of LVH evident. HCM causes variable symptoms and is one of the leading causes of sudden cardiac death (SCD) in young adults. While various phenotypic features of HCM among monozygotic twin pairs are not uncommonly reported, occurrence of synchronous cardiac arrest among them is not known from literature. CASE PRESENTATION: We present a case of monozygotic twins with HCM who both had a cardiac arrest post physical exertion in 63(rd) year of their lives. CONCLUSION: This case highlights potential genetics predisposition of cardiac arrest in patients with HCM despite having different phenotypic expression. SCD may be the only manifestation of patients with HCM. Decision of implantable cardioverter-defibrillator (ICD) placement for primary prevention of SCD should be based on the recommended guidelines, clinical judgment and patient’s preference. BioMed Central 2015-02-28 /pmc/articles/PMC4367866/ /pubmed/25885451 http://dx.doi.org/10.1186/s12872-015-0007-3 Text en © Goh et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Goh, Cheng Yee ul Haq, Muhammad Asrar Mutha, Vivek van Gaal, William J Synchronous cardiac arrest in monozygotic twins with hypertrophic cardiomyopathy - Is sudden cardiac death genetically pre-programmed? |
title | Synchronous cardiac arrest in monozygotic twins with hypertrophic cardiomyopathy - Is sudden cardiac death genetically pre-programmed? |
title_full | Synchronous cardiac arrest in monozygotic twins with hypertrophic cardiomyopathy - Is sudden cardiac death genetically pre-programmed? |
title_fullStr | Synchronous cardiac arrest in monozygotic twins with hypertrophic cardiomyopathy - Is sudden cardiac death genetically pre-programmed? |
title_full_unstemmed | Synchronous cardiac arrest in monozygotic twins with hypertrophic cardiomyopathy - Is sudden cardiac death genetically pre-programmed? |
title_short | Synchronous cardiac arrest in monozygotic twins with hypertrophic cardiomyopathy - Is sudden cardiac death genetically pre-programmed? |
title_sort | synchronous cardiac arrest in monozygotic twins with hypertrophic cardiomyopathy - is sudden cardiac death genetically pre-programmed? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367866/ https://www.ncbi.nlm.nih.gov/pubmed/25885451 http://dx.doi.org/10.1186/s12872-015-0007-3 |
work_keys_str_mv | AT gohchengyee synchronouscardiacarrestinmonozygotictwinswithhypertrophiccardiomyopathyissuddencardiacdeathgeneticallypreprogrammed AT ulhaqmuhammadasrar synchronouscardiacarrestinmonozygotictwinswithhypertrophiccardiomyopathyissuddencardiacdeathgeneticallypreprogrammed AT muthavivek synchronouscardiacarrestinmonozygotictwinswithhypertrophiccardiomyopathyissuddencardiacdeathgeneticallypreprogrammed AT vangaalwilliamj synchronouscardiacarrestinmonozygotictwinswithhypertrophiccardiomyopathyissuddencardiacdeathgeneticallypreprogrammed |