Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours

BACKGROUND: Neurofibromatosis type-1 (NF1) is a complex neurogenetic disorder characterised by the development of benign and malignant tumours of the peripheral nerve sheath (MPNSTs). Whilst biallelic NF1 gene inactivation contributes to benign tumour formation, additional cellular changes in gene s...

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Detalles Bibliográficos
Autores principales: Thomas, Laura E, Winston, Jincy, Rad, Ellie, Mort, Matthew, Dodd, Kayleigh M, Tee, Andrew R, McDyer, Fionnuala, Moore, Stephen, Cooper, David N, Upadhyaya, Meena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367978/
https://www.ncbi.nlm.nih.gov/pubmed/25884485
http://dx.doi.org/10.1186/s40246-015-0025-3

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