Benzodiazepinone Derivatives Protect against Endoplasmic Reticulum Stress-Mediated Cell Death in Human Neuronal Cell Lines

[Image: see text] Endoplasmic reticulum (ER) stress causes neuronal dysfunction followed by cell death and is recognized as a feature of many neurodegenerative diseases. Using a phenotypic screen, we recently identified benzodiazepinone derivatives that reduce ER stress-mediated apoptosis in a rat n...

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Detalles Bibliográficos
Autores principales: Zou, Haixia, Limpert, Allison S., Zou, Jiwen, Dembo, Anna, Lee, Pooi-San, Grant, Daniel, Ardecky, Robert, Pinkerton, Anthony B., Magnuson, Gavin K., Goldman, Mark E., Rong, Juan, Teriete, Peter, Sheffler, Douglas J., Reed, John C., Cosford, Nicholas D. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368043/
https://www.ncbi.nlm.nih.gov/pubmed/25544056
http://dx.doi.org/10.1021/cn500297v

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