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Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas

MicroRNAs are short single-stranded non-coding RNA molecules that function as regulators of tumor progression, including regulation of glioblastoma multiforme, which is a World Health Organization grade IV glioma. Based on the results of a microRNA microarray, which included 198 patients with glioma...

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Autores principales: YANG, XUE, ZHANG, CHUANBAO, GUO, TIANZHU, FENG, YING, LIU, QINGYANG, CHEN, YAN, ZHANG, QUANGENG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368077/
https://www.ncbi.nlm.nih.gov/pubmed/25572712
http://dx.doi.org/10.3892/mmr.2015.3171
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author YANG, XUE
ZHANG, CHUANBAO
GUO, TIANZHU
FENG, YING
LIU, QINGYANG
CHEN, YAN
ZHANG, QUANGENG
author_facet YANG, XUE
ZHANG, CHUANBAO
GUO, TIANZHU
FENG, YING
LIU, QINGYANG
CHEN, YAN
ZHANG, QUANGENG
author_sort YANG, XUE
collection PubMed
description MicroRNAs are short single-stranded non-coding RNA molecules that function as regulators of tumor progression, including regulation of glioblastoma multiforme, which is a World Health Organization grade IV glioma. Based on the results of a microRNA microarray, which included 198 patients with glioma from the Chinese Glioma Genome Atlas data set, it was observed that microRNA-206 (miR-206) was downregulated in high-grade (grades III and IV) gliomas compared with grade II gliomas. In addition, high expression of miR-206 was associated with longer overall survival time in glioma patients. The present study aimed to investigate the biological functions of miR-206 in glioma progression in vitro using the LN229 glioma cell line. Cell proliferation was observed to be inhibited subsequent to transfection with miR-206. It was suggested that miR-206 induced cell cycle G(1)/S phase arrest by suppressing the expression of cyclinD2. The results of the present study concluded that miR-206 inhibits glioma progression via the regulation of cyclinD2 and that miR-206 may be a novel biomarker with potential for use as a therapeutic target in gliomas.
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spelling pubmed-43680772015-03-26 Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas YANG, XUE ZHANG, CHUANBAO GUO, TIANZHU FENG, YING LIU, QINGYANG CHEN, YAN ZHANG, QUANGENG Mol Med Rep Articles MicroRNAs are short single-stranded non-coding RNA molecules that function as regulators of tumor progression, including regulation of glioblastoma multiforme, which is a World Health Organization grade IV glioma. Based on the results of a microRNA microarray, which included 198 patients with glioma from the Chinese Glioma Genome Atlas data set, it was observed that microRNA-206 (miR-206) was downregulated in high-grade (grades III and IV) gliomas compared with grade II gliomas. In addition, high expression of miR-206 was associated with longer overall survival time in glioma patients. The present study aimed to investigate the biological functions of miR-206 in glioma progression in vitro using the LN229 glioma cell line. Cell proliferation was observed to be inhibited subsequent to transfection with miR-206. It was suggested that miR-206 induced cell cycle G(1)/S phase arrest by suppressing the expression of cyclinD2. The results of the present study concluded that miR-206 inhibits glioma progression via the regulation of cyclinD2 and that miR-206 may be a novel biomarker with potential for use as a therapeutic target in gliomas. D.A. Spandidos 2015-05 2015-01-09 /pmc/articles/PMC4368077/ /pubmed/25572712 http://dx.doi.org/10.3892/mmr.2015.3171 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
YANG, XUE
ZHANG, CHUANBAO
GUO, TIANZHU
FENG, YING
LIU, QINGYANG
CHEN, YAN
ZHANG, QUANGENG
Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas
title Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas
title_full Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas
title_fullStr Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas
title_full_unstemmed Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas
title_short Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas
title_sort reduced expression of microrna-206 regulates cell proliferation via cyclind2 in gliomas
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368077/
https://www.ncbi.nlm.nih.gov/pubmed/25572712
http://dx.doi.org/10.3892/mmr.2015.3171
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