Cargando…
Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design
The Plasmodium vivax vaccine candidate Duffy Binding Protein (DBP) is a protein necessary for P. vivax invasion of reticulocytes. The polymorphic nature of DBP induces strain-specific immune responses that pose unique challenges for vaccine development. DEKnull is a synthetic DBP based antigen that...
Autores principales: | Chen, Edwin, Salinas, Nichole D., Ntumngia, Francis B., Adams, John H., Tolia, Niraj H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368114/ https://www.ncbi.nlm.nih.gov/pubmed/25793371 http://dx.doi.org/10.1371/journal.pntd.0003644 |
Ejemplares similares
-
An engineered vaccine of the Plasmodium vivax Duffy binding protein enhances induction of broadly neutralizing antibodies
por: Ntumngia, Francis B., et al.
Publicado: (2017) -
Plasmodium vivax Duffy binding protein: understanding targets of protective immunity
por: Adams, John H, et al.
Publicado: (2014) -
Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC
por: Batchelor, Joseph D., et al.
Publicado: (2011) -
Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC
por: Batchelor, Joseph D., et al.
Publicado: (2014) -
Determination of the Molecular Basis for a Limited Dimorphism, N417K, in the Plasmodium vivax Duffy-Binding Protein
por: McHenry, Amy M., et al.
Publicado: (2011)