Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy

Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape and negatively correlate with overall survival of cancer patients. Nowadays, a variety of methods to target MDSCs are being investigated. Based on the intervention stage of MDSCs, namely development, expansion and ac...

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Detalles Bibliográficos
Autores principales: Draghiciu, Oana, Lubbers, Joyce, Nijman, Hans W, Daemen, Toos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368153/
https://www.ncbi.nlm.nih.gov/pubmed/25949858
http://dx.doi.org/10.4161/21624011.2014.954829
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author Draghiciu, Oana
Lubbers, Joyce
Nijman, Hans W
Daemen, Toos
author_facet Draghiciu, Oana
Lubbers, Joyce
Nijman, Hans W
Daemen, Toos
author_sort Draghiciu, Oana
collection PubMed
description Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape and negatively correlate with overall survival of cancer patients. Nowadays, a variety of methods to target MDSCs are being investigated. Based on the intervention stage of MDSCs, namely development, expansion and activation, function and turnover, these methods can be divided into: (I) prevention or differentiation to mature cells, (II) blockade of MDSC expansion and activation, (III) inhibition of MDSC suppressive activity or (IV) depletion of intratumoral MDSCs. This review describes effective mono- or multimodal-therapies that target MDSCs for the benefit of cancer treatment.
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spelling pubmed-43681532016-02-03 Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy Draghiciu, Oana Lubbers, Joyce Nijman, Hans W Daemen, Toos Oncoimmunology Review Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape and negatively correlate with overall survival of cancer patients. Nowadays, a variety of methods to target MDSCs are being investigated. Based on the intervention stage of MDSCs, namely development, expansion and activation, function and turnover, these methods can be divided into: (I) prevention or differentiation to mature cells, (II) blockade of MDSC expansion and activation, (III) inhibition of MDSC suppressive activity or (IV) depletion of intratumoral MDSCs. This review describes effective mono- or multimodal-therapies that target MDSCs for the benefit of cancer treatment. Taylor & Francis 2015-02-03 /pmc/articles/PMC4368153/ /pubmed/25949858 http://dx.doi.org/10.4161/21624011.2014.954829 Text en © 2015 Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Draghiciu, Oana
Lubbers, Joyce
Nijman, Hans W
Daemen, Toos
Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy
title Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy
title_full Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy
title_fullStr Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy
title_full_unstemmed Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy
title_short Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy
title_sort myeloid derived suppressor cells—an overview of combat strategies to increase immunotherapy efficacy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368153/
https://www.ncbi.nlm.nih.gov/pubmed/25949858
http://dx.doi.org/10.4161/21624011.2014.954829
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