Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity

Although runt-related transcription factor 2 (RUNX2) is known to be an essential key transcription factor for osteoblast differentiation and bone formation, RUNX2 also plays a pivotal role in the regulation of p53-dependent DNA damage response. In the present study, we report that, in addition to p5...

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Detalles Bibliográficos
Autores principales: Ozaki, Toshinori, Sugimoto, Hirokazu, Nakamura, Mizuyo, Hiraoka, Kiriko, Yoda, Hiroyuki, Sang, Meixiang, Fujiwara, Kyoko, Nagase, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368372/
https://www.ncbi.nlm.nih.gov/pubmed/25331851
http://dx.doi.org/10.1111/febs.13108

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