Crystal Structure of the Eukaryotic Origin Recognition Complex

Initiation of cellular DNA replication is tightly controlled to sustain genomic integrity. In eukaryotes, the heterohexameric origin recognition complex (ORC) is essential for coordinating replication onset. The 3.5 Å resolution crystal structure of Drosophila ORC reveals that the 270 kDa initiator...

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Detalles Bibliográficos
Autores principales: Bleichert, Franziska, Botchan, Michael R., Berger, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368505/
https://www.ncbi.nlm.nih.gov/pubmed/25762138
http://dx.doi.org/10.1038/nature14239

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