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TLR7 Influences Germinal Center Selection in Murine SLE

TLR7 enhances germinal center maturation and migration of B cells to the dark zone where proliferation and somatic hypermutation occur. Our goal was to determine how Tlr7 dose influences selection of the autoreactive B cell repertoire in NZW/BXSB. Yaa mice bearing the site-directed heavy chain trans...

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Detalles Bibliográficos
Autores principales:	Boneparth, Alexis, Huang, Weiqing, Bethunaickan, Ramalingam, Woods, Megan, Sahu, Ranjit, Arora, Shitij, Akerman, Meredith, Lesser, Martin, Davidson, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368537/ https://www.ncbi.nlm.nih.gov/pubmed/25794167 http://dx.doi.org/10.1371/journal.pone.0119925

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