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Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate

The Hedgehog (Hh) signaling pathway mediates multiple spatiotemporally-specific aspects of brain and face development. Genetic and chemical disruptions of the pathway are known to result in an array of structural malformations, including holoprosencephaly (HPE), clefts of the lip with or without cle...

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Detalles Bibliográficos
Autores principales:	Heyne, Galen W., Melberg, Cal G., Doroodchi, Padydeh, Parins, Kia F., Kietzman, Henry W., Everson, Joshua L., Ansen-Wilson, Lydia J., Lipinski, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368540/ https://www.ncbi.nlm.nih.gov/pubmed/25793997 http://dx.doi.org/10.1371/journal.pone.0120517

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