Cargando…
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
OBJECTIVE: Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. The catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368617/ https://www.ncbi.nlm.nih.gov/pubmed/25793616 http://dx.doi.org/10.1371/journal.pone.0119592 |
_version_ | 1782362650106134528 |
---|---|
author | Sampaio, Aline Santos Hounie, Ana Gabriela Petribú, Kátia Cappi, Carolina Morais, Ivanil Vallada, Homero do Rosário, Maria Conceição Stewart, S. Evelyn Fargeness, Jesen Mathews, Carol Arnold, Paul Hanna, Gregory L. Richter, Margaret Kennedy, James Fontenelle, Leonardo de Bragança Pereira, Carlos Alberto Pauls, David L. Miguel, Eurípedes Constantino |
author_facet | Sampaio, Aline Santos Hounie, Ana Gabriela Petribú, Kátia Cappi, Carolina Morais, Ivanil Vallada, Homero do Rosário, Maria Conceição Stewart, S. Evelyn Fargeness, Jesen Mathews, Carol Arnold, Paul Hanna, Gregory L. Richter, Margaret Kennedy, James Fontenelle, Leonardo de Bragança Pereira, Carlos Alberto Pauls, David L. Miguel, Eurípedes Constantino |
author_sort | Sampaio, Aline Santos |
collection | PubMed |
description | OBJECTIVE: Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. The catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor (2013) in a comprehensive meta-analysis of genetic association studies has identified COMT and MAO-A polymorphisms involved with OCD. In an effort to clarify the role of these two genes in OCD vulnerability, a family-based association investigation was performed as an alternative strategy to the classical case-control design. METHODS: Transmission disequilibrium analyses were performed after genotyping 13 single-nucleotide polymorphisms (eight in COMT and five in MAO-A) in 783 OCD trios (probands and their parents). Four different OCD phenotypes (from narrow to broad OCD definitions) and a SNP x SNP epistasis were also analyzed. RESULTS: OCD, broad and narrow phenotypes,were not associated with any of the investigated COMT and MAO-A polymorphisms. In addition, the analyses of gene-gene interaction did not show significant epistatic influences on phenotype between COMT and MAO-A. CONCLUSIONS: The findings do not support an association between DSM-IV OCD and the variants of COMT or MAO-A. However, results from this study cannot exclude the contribution of these genes in the manifestation of OCD. The evaluation of broader spectrum phenotypes could help to understand the role of these and other genes in the pathophysiology of OCD and its spectrum disorders. |
format | Online Article Text |
id | pubmed-4368617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43686172015-03-27 COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study Sampaio, Aline Santos Hounie, Ana Gabriela Petribú, Kátia Cappi, Carolina Morais, Ivanil Vallada, Homero do Rosário, Maria Conceição Stewart, S. Evelyn Fargeness, Jesen Mathews, Carol Arnold, Paul Hanna, Gregory L. Richter, Margaret Kennedy, James Fontenelle, Leonardo de Bragança Pereira, Carlos Alberto Pauls, David L. Miguel, Eurípedes Constantino PLoS One Research Article OBJECTIVE: Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. The catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor (2013) in a comprehensive meta-analysis of genetic association studies has identified COMT and MAO-A polymorphisms involved with OCD. In an effort to clarify the role of these two genes in OCD vulnerability, a family-based association investigation was performed as an alternative strategy to the classical case-control design. METHODS: Transmission disequilibrium analyses were performed after genotyping 13 single-nucleotide polymorphisms (eight in COMT and five in MAO-A) in 783 OCD trios (probands and their parents). Four different OCD phenotypes (from narrow to broad OCD definitions) and a SNP x SNP epistasis were also analyzed. RESULTS: OCD, broad and narrow phenotypes,were not associated with any of the investigated COMT and MAO-A polymorphisms. In addition, the analyses of gene-gene interaction did not show significant epistatic influences on phenotype between COMT and MAO-A. CONCLUSIONS: The findings do not support an association between DSM-IV OCD and the variants of COMT or MAO-A. However, results from this study cannot exclude the contribution of these genes in the manifestation of OCD. The evaluation of broader spectrum phenotypes could help to understand the role of these and other genes in the pathophysiology of OCD and its spectrum disorders. Public Library of Science 2015-03-20 /pmc/articles/PMC4368617/ /pubmed/25793616 http://dx.doi.org/10.1371/journal.pone.0119592 Text en © 2015 Sampaio et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Sampaio, Aline Santos Hounie, Ana Gabriela Petribú, Kátia Cappi, Carolina Morais, Ivanil Vallada, Homero do Rosário, Maria Conceição Stewart, S. Evelyn Fargeness, Jesen Mathews, Carol Arnold, Paul Hanna, Gregory L. Richter, Margaret Kennedy, James Fontenelle, Leonardo de Bragança Pereira, Carlos Alberto Pauls, David L. Miguel, Eurípedes Constantino COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title_full |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title_fullStr |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title_full_unstemmed |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title_short |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title_sort | comt and mao-a polymorphisms and obsessive-compulsive disorder: a family-based association study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368617/ https://www.ncbi.nlm.nih.gov/pubmed/25793616 http://dx.doi.org/10.1371/journal.pone.0119592 |
work_keys_str_mv | AT sampaioalinesantos comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT hounieanagabriela comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT petribukatia comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT cappicarolina comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT moraisivanil comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT valladahomero comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT dorosariomariaconceicao comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT stewartsevelyn comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT fargenessjesen comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT mathewscarol comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT arnoldpaul comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT hannagregoryl comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT richtermargaret comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT kennedyjames comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT fontenelleleonardo comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT debragancapereiracarlosalberto comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT paulsdavidl comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy AT migueleuripedesconstantino comtandmaoapolymorphismsandobsessivecompulsivedisorderafamilybasedassociationstudy |