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COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study

OBJECTIVE: Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. The catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A...

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Autores principales: Sampaio, Aline Santos, Hounie, Ana Gabriela, Petribú, Kátia, Cappi, Carolina, Morais, Ivanil, Vallada, Homero, do Rosário, Maria Conceição, Stewart, S. Evelyn, Fargeness, Jesen, Mathews, Carol, Arnold, Paul, Hanna, Gregory L., Richter, Margaret, Kennedy, James, Fontenelle, Leonardo, de Bragança Pereira, Carlos Alberto, Pauls, David L., Miguel, Eurípedes Constantino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368617/
https://www.ncbi.nlm.nih.gov/pubmed/25793616
http://dx.doi.org/10.1371/journal.pone.0119592
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author Sampaio, Aline Santos
Hounie, Ana Gabriela
Petribú, Kátia
Cappi, Carolina
Morais, Ivanil
Vallada, Homero
do Rosário, Maria Conceição
Stewart, S. Evelyn
Fargeness, Jesen
Mathews, Carol
Arnold, Paul
Hanna, Gregory L.
Richter, Margaret
Kennedy, James
Fontenelle, Leonardo
de Bragança Pereira, Carlos Alberto
Pauls, David L.
Miguel, Eurípedes Constantino
author_facet Sampaio, Aline Santos
Hounie, Ana Gabriela
Petribú, Kátia
Cappi, Carolina
Morais, Ivanil
Vallada, Homero
do Rosário, Maria Conceição
Stewart, S. Evelyn
Fargeness, Jesen
Mathews, Carol
Arnold, Paul
Hanna, Gregory L.
Richter, Margaret
Kennedy, James
Fontenelle, Leonardo
de Bragança Pereira, Carlos Alberto
Pauls, David L.
Miguel, Eurípedes Constantino
author_sort Sampaio, Aline Santos
collection PubMed
description OBJECTIVE: Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. The catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor (2013) in a comprehensive meta-analysis of genetic association studies has identified COMT and MAO-A polymorphisms involved with OCD. In an effort to clarify the role of these two genes in OCD vulnerability, a family-based association investigation was performed as an alternative strategy to the classical case-control design. METHODS: Transmission disequilibrium analyses were performed after genotyping 13 single-nucleotide polymorphisms (eight in COMT and five in MAO-A) in 783 OCD trios (probands and their parents). Four different OCD phenotypes (from narrow to broad OCD definitions) and a SNP x SNP epistasis were also analyzed. RESULTS: OCD, broad and narrow phenotypes,were not associated with any of the investigated COMT and MAO-A polymorphisms. In addition, the analyses of gene-gene interaction did not show significant epistatic influences on phenotype between COMT and MAO-A. CONCLUSIONS: The findings do not support an association between DSM-IV OCD and the variants of COMT or MAO-A. However, results from this study cannot exclude the contribution of these genes in the manifestation of OCD. The evaluation of broader spectrum phenotypes could help to understand the role of these and other genes in the pathophysiology of OCD and its spectrum disorders.
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spelling pubmed-43686172015-03-27 COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study Sampaio, Aline Santos Hounie, Ana Gabriela Petribú, Kátia Cappi, Carolina Morais, Ivanil Vallada, Homero do Rosário, Maria Conceição Stewart, S. Evelyn Fargeness, Jesen Mathews, Carol Arnold, Paul Hanna, Gregory L. Richter, Margaret Kennedy, James Fontenelle, Leonardo de Bragança Pereira, Carlos Alberto Pauls, David L. Miguel, Eurípedes Constantino PLoS One Research Article OBJECTIVE: Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. The catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor (2013) in a comprehensive meta-analysis of genetic association studies has identified COMT and MAO-A polymorphisms involved with OCD. In an effort to clarify the role of these two genes in OCD vulnerability, a family-based association investigation was performed as an alternative strategy to the classical case-control design. METHODS: Transmission disequilibrium analyses were performed after genotyping 13 single-nucleotide polymorphisms (eight in COMT and five in MAO-A) in 783 OCD trios (probands and their parents). Four different OCD phenotypes (from narrow to broad OCD definitions) and a SNP x SNP epistasis were also analyzed. RESULTS: OCD, broad and narrow phenotypes,were not associated with any of the investigated COMT and MAO-A polymorphisms. In addition, the analyses of gene-gene interaction did not show significant epistatic influences on phenotype between COMT and MAO-A. CONCLUSIONS: The findings do not support an association between DSM-IV OCD and the variants of COMT or MAO-A. However, results from this study cannot exclude the contribution of these genes in the manifestation of OCD. The evaluation of broader spectrum phenotypes could help to understand the role of these and other genes in the pathophysiology of OCD and its spectrum disorders. Public Library of Science 2015-03-20 /pmc/articles/PMC4368617/ /pubmed/25793616 http://dx.doi.org/10.1371/journal.pone.0119592 Text en © 2015 Sampaio et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sampaio, Aline Santos
Hounie, Ana Gabriela
Petribú, Kátia
Cappi, Carolina
Morais, Ivanil
Vallada, Homero
do Rosário, Maria Conceição
Stewart, S. Evelyn
Fargeness, Jesen
Mathews, Carol
Arnold, Paul
Hanna, Gregory L.
Richter, Margaret
Kennedy, James
Fontenelle, Leonardo
de Bragança Pereira, Carlos Alberto
Pauls, David L.
Miguel, Eurípedes Constantino
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
title COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
title_full COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
title_fullStr COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
title_full_unstemmed COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
title_short COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
title_sort comt and mao-a polymorphisms and obsessive-compulsive disorder: a family-based association study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368617/
https://www.ncbi.nlm.nih.gov/pubmed/25793616
http://dx.doi.org/10.1371/journal.pone.0119592
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