Expression of Dominant-Negative Thyroid Hormone Receptor Alpha1 in Leydig and Sertoli Cells Demonstrates No Additional Defect Compared with Expression in Sertoli Cells Only

BACKGROUND: In the testis, thyroid hormone (T3) regulates the number of gametes produced through its action on Sertoli cell proliferation. However, the role of T3 in the regulation of steroidogenesis is still controversial. METHODS: The TRα(AMI) knock-in allele allows the generation of transgenic mi...

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Detalles Bibliográficos
Autores principales: Fumel, Betty, Froment, Pascal, Holzenberger, Martin, Livera, Gabriel, Monget, Philippe, Fouchécourt, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368620/
https://www.ncbi.nlm.nih.gov/pubmed/25793522
http://dx.doi.org/10.1371/journal.pone.0119392

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