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Systematic Review on Irrational Use of Medicines in China and Vietnam

BACKGROUND: Irrational use of medicines has been an issue concerned all over the world and the outlooks in developing countries are more severe. This study aimed to assess the different patterns of irrational use of medicines and its influential factors in China and Vietnam. METHODS: A systematic re...

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Autores principales: Mao, Wenhui, Vu, Huyen, Xie, Zening, Chen, Wen, Tang, Shenglan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368648/
https://www.ncbi.nlm.nih.gov/pubmed/25793497
http://dx.doi.org/10.1371/journal.pone.0117710
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author Mao, Wenhui
Vu, Huyen
Xie, Zening
Chen, Wen
Tang, Shenglan
author_facet Mao, Wenhui
Vu, Huyen
Xie, Zening
Chen, Wen
Tang, Shenglan
author_sort Mao, Wenhui
collection PubMed
description BACKGROUND: Irrational use of medicines has been an issue concerned all over the world and the outlooks in developing countries are more severe. This study aimed to assess the different patterns of irrational use of medicines and its influential factors in China and Vietnam. METHODS: A systematic review was performed on both published and grey literatures in English, Chinese and Vietnamese languages between 1993 and 2013 based on the WHO framework. Quality assessment was conducted on the basis of the Critical Appraisal Skills Programme. Key indicators were analyzed to compare the irrational use of medicines in two countries. RESULTS: A total of 67 published works about China and 29 about Vietnam were included, the majority of which were cross-sectional prescription studies in both China and Vietnam. Irrational use of medicines was found in both the countries but issues with polypharmacy as well as overuse of antibiotics were more severe in Vietnam while overuse of injections was unique to China. Various patterns of irrational use were also indicated between urban and rural areas, and among different levels of hospitals. Rarely does literature focus on the analysis of influential factors of irrational use of medicines. While lack of proper knowledge from both providers and patients were the most recognized influential factors in both countries, economic incentives from pharmaceutical companies in China, and weak control and regulation over prescriptions in Vietnam were the main factors attributed to this issue. CONCLUSION: Severe irrational use of medicines has been abundantly evidenced in both China and Vietnam, highlighting the importance of policy interventions on the issue. However, limited evidence on the appropriateness or its compliance (conformity) to guidelines of prescription has been found. In addition, convincing evidence on the underlying explanation of this issue is lacking, although economic incentives, health insurance coverage, and knowledge of service providers and users have been implied to be factors influencing irrational drug use.
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spelling pubmed-43686482015-03-27 Systematic Review on Irrational Use of Medicines in China and Vietnam Mao, Wenhui Vu, Huyen Xie, Zening Chen, Wen Tang, Shenglan PLoS One Research Article BACKGROUND: Irrational use of medicines has been an issue concerned all over the world and the outlooks in developing countries are more severe. This study aimed to assess the different patterns of irrational use of medicines and its influential factors in China and Vietnam. METHODS: A systematic review was performed on both published and grey literatures in English, Chinese and Vietnamese languages between 1993 and 2013 based on the WHO framework. Quality assessment was conducted on the basis of the Critical Appraisal Skills Programme. Key indicators were analyzed to compare the irrational use of medicines in two countries. RESULTS: A total of 67 published works about China and 29 about Vietnam were included, the majority of which were cross-sectional prescription studies in both China and Vietnam. Irrational use of medicines was found in both the countries but issues with polypharmacy as well as overuse of antibiotics were more severe in Vietnam while overuse of injections was unique to China. Various patterns of irrational use were also indicated between urban and rural areas, and among different levels of hospitals. Rarely does literature focus on the analysis of influential factors of irrational use of medicines. While lack of proper knowledge from both providers and patients were the most recognized influential factors in both countries, economic incentives from pharmaceutical companies in China, and weak control and regulation over prescriptions in Vietnam were the main factors attributed to this issue. CONCLUSION: Severe irrational use of medicines has been abundantly evidenced in both China and Vietnam, highlighting the importance of policy interventions on the issue. However, limited evidence on the appropriateness or its compliance (conformity) to guidelines of prescription has been found. In addition, convincing evidence on the underlying explanation of this issue is lacking, although economic incentives, health insurance coverage, and knowledge of service providers and users have been implied to be factors influencing irrational drug use. Public Library of Science 2015-03-20 /pmc/articles/PMC4368648/ /pubmed/25793497 http://dx.doi.org/10.1371/journal.pone.0117710 Text en © 2015 Mao et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mao, Wenhui
Vu, Huyen
Xie, Zening
Chen, Wen
Tang, Shenglan
Systematic Review on Irrational Use of Medicines in China and Vietnam
title Systematic Review on Irrational Use of Medicines in China and Vietnam
title_full Systematic Review on Irrational Use of Medicines in China and Vietnam
title_fullStr Systematic Review on Irrational Use of Medicines in China and Vietnam
title_full_unstemmed Systematic Review on Irrational Use of Medicines in China and Vietnam
title_short Systematic Review on Irrational Use of Medicines in China and Vietnam
title_sort systematic review on irrational use of medicines in china and vietnam
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368648/
https://www.ncbi.nlm.nih.gov/pubmed/25793497
http://dx.doi.org/10.1371/journal.pone.0117710
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