Validation of a Rapid and Sensitive LC-MS/MS Method for Determination of Exemestane and Its Metabolites, 17β-Hydroxyexemestane and 17β-Hydroxyexemestane-17-O-β-D-Glucuronide: Application to Human Pharmacokinetics Study

A novel, rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the evaluation of exemestane pharmacokinetics and its metabolites, 17β-dihydroexemestane (active metabolite) and 17β-dihydroexemestane-17-O-β-D-glucuronide (inactive metabol...

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Detalles Bibliográficos
Autores principales: Wang, Ling-Zhi, Goh, Sok-Hwei, Wong, Andrea Li-Ann, Thuya, Win-Lwin, Lau, Jie-Ying Amelia, Wan, Seow-Ching, Lee, Soo-Chin, Ho, Paul C., Goh, Boon-Cher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368747/
https://www.ncbi.nlm.nih.gov/pubmed/25793887
http://dx.doi.org/10.1371/journal.pone.0118553

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