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Characterization of a Novel Mutation in NS1 Protein of Influenza A Virus Induced by a Chemical Substance for the Attenuation of Pathogenicity

It is generally accepted that live attenuated influenza vaccine (LAIV) has the potential for use as a vaccination against flu. In this study, we demonstrated the nature of an influenza A virus (IAV) mutant induced by treating the IAV with a stable furan derivative, (1R,2R)-1-(5’-methylfur-3’-yl)prop...

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Detalles Bibliográficos
Autores principales: Sasaki, Kohei, Hayashi, Kyoko, Lee, Jung-Bum, Kurosaki, Fumiya, Hayashi, Toshimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368802/
https://www.ncbi.nlm.nih.gov/pubmed/25793397
http://dx.doi.org/10.1371/journal.pone.0121205