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Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1

Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization. PLCs are classified into structurally distinct β, γ, δ, ε, ζ, and η isoforms. There are two PLCγ isoforms (PLCγ1, PLCγ2), which are critical fo...

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Detalles Bibliográficos
Autores principales:	Zheng, Yongwei, Adams, Tamara, Zhi, Huiying, Yu, Mei, Wen, Renren, Newman, Peter J., Wang, Demin, Newman, Debra K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368822/ https://www.ncbi.nlm.nih.gov/pubmed/25793864 http://dx.doi.org/10.1371/journal.pone.0119739

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