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A Randomized Controlled Trial of Brief and Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy

BACKGROUND: Some studies suggest better overall outcomes when right unilateral electroconvulsive therapy (RUL ECT) is given with an ultrabrief, rather than brief, pulse width. METHODS: The aim of the study was to test if ultrabrief-pulse RUL ECT results in less cognitive side effects than brief- pul...

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Autores principales: Loo, Colleen K., Katalinic, Natalie, Smith, Deirdre J., Ingram, Anna, Dowling, Nathan, Martin, Donel, Addison, Kerryn, Hadzi-Pavlovic, Dusan, Simpson, Brett, Schweitzer,, Isaac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368876/
https://www.ncbi.nlm.nih.gov/pubmed/25522389
http://dx.doi.org/10.1093/ijnp/pyu045
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author Loo, Colleen K.
Katalinic, Natalie
Smith, Deirdre J.
Ingram, Anna
Dowling, Nathan
Martin, Donel
Addison, Kerryn
Hadzi-Pavlovic, Dusan
Simpson, Brett
Schweitzer,, Isaac
author_facet Loo, Colleen K.
Katalinic, Natalie
Smith, Deirdre J.
Ingram, Anna
Dowling, Nathan
Martin, Donel
Addison, Kerryn
Hadzi-Pavlovic, Dusan
Simpson, Brett
Schweitzer,, Isaac
author_sort Loo, Colleen K.
collection PubMed
description BACKGROUND: Some studies suggest better overall outcomes when right unilateral electroconvulsive therapy (RUL ECT) is given with an ultrabrief, rather than brief, pulse width. METHODS: The aim of the study was to test if ultrabrief-pulse RUL ECT results in less cognitive side effects than brief- pulse RUL ECT, when given at doses which achieve comparable efficacy. One hundred and two participants were assigned to receive ultrabrief (at 8 times seizure threshold) or brief (at 5 times seizure threshold) pulse RUL ECT in a double-blind, randomized controlled trial. Blinded raters assessed mood and cognitive functioning over the ECT course. RESULTS: Efficacy outcomes were not found to be significantly different. The ultrabrief group showed less cognitive impairment immediately after a single session of ECT, and over the treatment course (autobiographical memory, orientation). CONCLUSIONS: In summary, when ultrabrief RUL ECT was given at a higher dosage than brief RUL ECT (8 versus 5 times seizure threshold), efficacy was comparable while cognitive impairment was less.
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spelling pubmed-43688762015-09-01 A Randomized Controlled Trial of Brief and Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy Loo, Colleen K. Katalinic, Natalie Smith, Deirdre J. Ingram, Anna Dowling, Nathan Martin, Donel Addison, Kerryn Hadzi-Pavlovic, Dusan Simpson, Brett Schweitzer,, Isaac Int J Neuropsychopharmacol Research Article BACKGROUND: Some studies suggest better overall outcomes when right unilateral electroconvulsive therapy (RUL ECT) is given with an ultrabrief, rather than brief, pulse width. METHODS: The aim of the study was to test if ultrabrief-pulse RUL ECT results in less cognitive side effects than brief- pulse RUL ECT, when given at doses which achieve comparable efficacy. One hundred and two participants were assigned to receive ultrabrief (at 8 times seizure threshold) or brief (at 5 times seizure threshold) pulse RUL ECT in a double-blind, randomized controlled trial. Blinded raters assessed mood and cognitive functioning over the ECT course. RESULTS: Efficacy outcomes were not found to be significantly different. The ultrabrief group showed less cognitive impairment immediately after a single session of ECT, and over the treatment course (autobiographical memory, orientation). CONCLUSIONS: In summary, when ultrabrief RUL ECT was given at a higher dosage than brief RUL ECT (8 versus 5 times seizure threshold), efficacy was comparable while cognitive impairment was less. Oxford University Press 2014-12-15 /pmc/articles/PMC4368876/ /pubmed/25522389 http://dx.doi.org/10.1093/ijnp/pyu045 Text en © The Author 2014. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Research Article
Loo, Colleen K.
Katalinic, Natalie
Smith, Deirdre J.
Ingram, Anna
Dowling, Nathan
Martin, Donel
Addison, Kerryn
Hadzi-Pavlovic, Dusan
Simpson, Brett
Schweitzer,, Isaac
A Randomized Controlled Trial of Brief and Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy
title A Randomized Controlled Trial of Brief and Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy
title_full A Randomized Controlled Trial of Brief and Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy
title_fullStr A Randomized Controlled Trial of Brief and Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy
title_full_unstemmed A Randomized Controlled Trial of Brief and Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy
title_short A Randomized Controlled Trial of Brief and Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy
title_sort randomized controlled trial of brief and ultrabrief pulse right unilateral electroconvulsive therapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368876/
https://www.ncbi.nlm.nih.gov/pubmed/25522389
http://dx.doi.org/10.1093/ijnp/pyu045
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