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Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene

BACKGROUND: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has mainly focused on its role as a histone deacetylase inhibitor (HDACi), there...

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Detalles Bibliográficos
Autores principales:	Wei, Ya Bin, Melas, Philippe A., Wegener, Gregers, Mathé, Aleksander A., Lavebratt, Catharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368891/ https://www.ncbi.nlm.nih.gov/pubmed/25618518 http://dx.doi.org/10.1093/ijnp/pyu032

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