Cargando…

Cardiovascular disease in HIV patients: from bench to bedside and backwards

HIV patients are exposed to a higher risk of adverse cardiovascular events, due to complex interactions between traditional risk factors and HIV infection itself in terms of ongoing endothelial dysfunctional immune activation/inflammation and increased risk of thrombosis. On the other hand, long-spa...

Descripción completa

Detalles Bibliográficos
Autores principales: Cerrato, Enrico, Calcagno, Andrea, D'Ascenzo, Fabrizio, Biondi-Zoccai, Giuseppe, Mancone, Massimo, Grosso Marra, Walter, Demarie, Daniela, Omedè, Pierluigi, Abbate, Antonio, Bonora, Stefano, DiNicolantonio, James J, Estrada, Vicente, Escaned, Javier, Moretti, Claudio, Gaita, Fiorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368980/
https://www.ncbi.nlm.nih.gov/pubmed/25815207
http://dx.doi.org/10.1136/openhrt-2014-000174
_version_ 1782362716273377280
author Cerrato, Enrico
Calcagno, Andrea
D'Ascenzo, Fabrizio
Biondi-Zoccai, Giuseppe
Mancone, Massimo
Grosso Marra, Walter
Demarie, Daniela
Omedè, Pierluigi
Abbate, Antonio
Bonora, Stefano
DiNicolantonio, James J
Estrada, Vicente
Escaned, Javier
Moretti, Claudio
Gaita, Fiorenzo
author_facet Cerrato, Enrico
Calcagno, Andrea
D'Ascenzo, Fabrizio
Biondi-Zoccai, Giuseppe
Mancone, Massimo
Grosso Marra, Walter
Demarie, Daniela
Omedè, Pierluigi
Abbate, Antonio
Bonora, Stefano
DiNicolantonio, James J
Estrada, Vicente
Escaned, Javier
Moretti, Claudio
Gaita, Fiorenzo
author_sort Cerrato, Enrico
collection PubMed
description HIV patients are exposed to a higher risk of adverse cardiovascular events, due to complex interactions between traditional risk factors and HIV infection itself in terms of ongoing endothelial dysfunctional immune activation/inflammation and increased risk of thrombosis. On the other hand, long-span antiretroviral therapy administration still raises questions on its long-term safety in an era in which life expectancy is becoming longer and longer while treatment of non-HIV-related serious events is increasingly raising concern. In this article, we will critically analyse the current knowledge of pathological and clinical aspects pertaining to the increased risk of cardiovascular events associated with HIV.
format Online
Article
Text
id pubmed-4368980
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-43689802015-03-26 Cardiovascular disease in HIV patients: from bench to bedside and backwards Cerrato, Enrico Calcagno, Andrea D'Ascenzo, Fabrizio Biondi-Zoccai, Giuseppe Mancone, Massimo Grosso Marra, Walter Demarie, Daniela Omedè, Pierluigi Abbate, Antonio Bonora, Stefano DiNicolantonio, James J Estrada, Vicente Escaned, Javier Moretti, Claudio Gaita, Fiorenzo Open Heart Special Populations HIV patients are exposed to a higher risk of adverse cardiovascular events, due to complex interactions between traditional risk factors and HIV infection itself in terms of ongoing endothelial dysfunctional immune activation/inflammation and increased risk of thrombosis. On the other hand, long-span antiretroviral therapy administration still raises questions on its long-term safety in an era in which life expectancy is becoming longer and longer while treatment of non-HIV-related serious events is increasingly raising concern. In this article, we will critically analyse the current knowledge of pathological and clinical aspects pertaining to the increased risk of cardiovascular events associated with HIV. BMJ Publishing Group 2015-03-20 /pmc/articles/PMC4368980/ /pubmed/25815207 http://dx.doi.org/10.1136/openhrt-2014-000174 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Special Populations
Cerrato, Enrico
Calcagno, Andrea
D'Ascenzo, Fabrizio
Biondi-Zoccai, Giuseppe
Mancone, Massimo
Grosso Marra, Walter
Demarie, Daniela
Omedè, Pierluigi
Abbate, Antonio
Bonora, Stefano
DiNicolantonio, James J
Estrada, Vicente
Escaned, Javier
Moretti, Claudio
Gaita, Fiorenzo
Cardiovascular disease in HIV patients: from bench to bedside and backwards
title Cardiovascular disease in HIV patients: from bench to bedside and backwards
title_full Cardiovascular disease in HIV patients: from bench to bedside and backwards
title_fullStr Cardiovascular disease in HIV patients: from bench to bedside and backwards
title_full_unstemmed Cardiovascular disease in HIV patients: from bench to bedside and backwards
title_short Cardiovascular disease in HIV patients: from bench to bedside and backwards
title_sort cardiovascular disease in hiv patients: from bench to bedside and backwards
topic Special Populations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368980/
https://www.ncbi.nlm.nih.gov/pubmed/25815207
http://dx.doi.org/10.1136/openhrt-2014-000174
work_keys_str_mv AT cerratoenrico cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT calcagnoandrea cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT dascenzofabrizio cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT biondizoccaigiuseppe cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT manconemassimo cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT grossomarrawalter cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT demariedaniela cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT omedepierluigi cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT abbateantonio cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT bonorastefano cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT dinicolantoniojamesj cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT estradavicente cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT escanedjavier cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT moretticlaudio cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards
AT gaitafiorenzo cardiovasculardiseaseinhivpatientsfrombenchtobedsideandbackwards