PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation to promote metastasis

Cancer cells can divert metabolites into anabolic pathways to support their rapid proliferation and to accumulate the cellular building blocks required for tumor growth. However, the specific bioenergetic profile of invasive and metastatic cancer cells is unknown. Here we report that migratory/invas...

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Detalles Bibliográficos
Autores principales: LeBleu, Valerie S., O'Connell, Joyce T., Herrera, Karina N. Gonzalez, Wikman-Kocher, Harriet, Pantel, Klaus, Haigis, Marcia C., de Carvalho, Fernanda Machado, Damascena, Aline, Chinen, Ludmilla Thome Domingos, Rocha, Rafael M., Asara, John M., Kalluri, Raghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369153/
https://www.ncbi.nlm.nih.gov/pubmed/25241037
http://dx.doi.org/10.1038/ncb3039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369153/
https://www.ncbi.nlm.nih.gov/pubmed/25241037
http://dx.doi.org/10.1038/ncb3039

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