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Erythrocyte indices in Pre-school Nigerian Children with Sickle Cell Anaemia in Steady State
BACKGROUND: Sickle cell disease is a genetic haemoglobinopathy with consequent haemolysis and anaemia. It is of interest to study its effect on red cell indices beside haemoglobin concentration. OBJECTIVES: The objective of the study is to determine the values of red cell indices in preschool-age ch...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369233/ https://www.ncbi.nlm.nih.gov/pubmed/25802694 |
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author | Akodu, Samuel Olufemi Njokanma, Olisamedua Fidelis AdeoluKehinde, Omolara |
author_facet | Akodu, Samuel Olufemi Njokanma, Olisamedua Fidelis AdeoluKehinde, Omolara |
author_sort | Akodu, Samuel Olufemi |
collection | PubMed |
description | BACKGROUND: Sickle cell disease is a genetic haemoglobinopathy with consequent haemolysis and anaemia. It is of interest to study its effect on red cell indices beside haemoglobin concentration. OBJECTIVES: The objective of the study is to determine the values of red cell indices in preschool-age children with sickle cell anaemia. METHODS: we conducted a cross-sectional study including 97 children with sickle cell anaemia aged six months to five years and 97 age-and sex-matched healthy controls with haemoglobin genotype AA (Hb AA). The red cell indices such as packed cell volume, haemoglobin concentration, mean corpuscular volume, red blood cell count, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were investigated, using an auto analyzer. RESULTS: The mean PCV, haemoglobin concentration and red blood cell count were significantly higher in HbAA controls (p = 0.000 in each case). The mean MCV was higher among HbSS subjects but it was only among females and when the result was analyzed irrespective of gender that the difference was statistically significant (p < 0.05). CONCLUSION: Children with sickle cell anaemia in steady state have lower values of all red cell parameters and higher values of MCV, compared to haemoglobin phenotype AA controls. |
format | Online Article Text |
id | pubmed-4369233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-43692332015-03-23 Erythrocyte indices in Pre-school Nigerian Children with Sickle Cell Anaemia in Steady State Akodu, Samuel Olufemi Njokanma, Olisamedua Fidelis AdeoluKehinde, Omolara Int J Hematol Oncol Stem Cell Res Original Article BACKGROUND: Sickle cell disease is a genetic haemoglobinopathy with consequent haemolysis and anaemia. It is of interest to study its effect on red cell indices beside haemoglobin concentration. OBJECTIVES: The objective of the study is to determine the values of red cell indices in preschool-age children with sickle cell anaemia. METHODS: we conducted a cross-sectional study including 97 children with sickle cell anaemia aged six months to five years and 97 age-and sex-matched healthy controls with haemoglobin genotype AA (Hb AA). The red cell indices such as packed cell volume, haemoglobin concentration, mean corpuscular volume, red blood cell count, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were investigated, using an auto analyzer. RESULTS: The mean PCV, haemoglobin concentration and red blood cell count were significantly higher in HbAA controls (p = 0.000 in each case). The mean MCV was higher among HbSS subjects but it was only among females and when the result was analyzed irrespective of gender that the difference was statistically significant (p < 0.05). CONCLUSION: Children with sickle cell anaemia in steady state have lower values of all red cell parameters and higher values of MCV, compared to haemoglobin phenotype AA controls. Tehran University of Medical Sciences 2015-01-01 /pmc/articles/PMC4369233/ /pubmed/25802694 Text en © 2013 Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Akodu, Samuel Olufemi Njokanma, Olisamedua Fidelis AdeoluKehinde, Omolara Erythrocyte indices in Pre-school Nigerian Children with Sickle Cell Anaemia in Steady State |
title | Erythrocyte indices in Pre-school Nigerian Children with Sickle Cell Anaemia in Steady State |
title_full | Erythrocyte indices in Pre-school Nigerian Children with Sickle Cell Anaemia in Steady State |
title_fullStr | Erythrocyte indices in Pre-school Nigerian Children with Sickle Cell Anaemia in Steady State |
title_full_unstemmed | Erythrocyte indices in Pre-school Nigerian Children with Sickle Cell Anaemia in Steady State |
title_short | Erythrocyte indices in Pre-school Nigerian Children with Sickle Cell Anaemia in Steady State |
title_sort | erythrocyte indices in pre-school nigerian children with sickle cell anaemia in steady state |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369233/ https://www.ncbi.nlm.nih.gov/pubmed/25802694 |
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