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Anti-tau antibody reduces insoluble tau and decreases brain atrophy

OBJECTIVE: We previously found a strong reduction in tau pathology and insoluble tau in P301S tau transgenic mice following intracerebroventricular infusion of the anti-tau antibody HJ8.5. We sought to determine the effects of HJ8.5 in the same model following peripheral administration. METHODS: The...

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Detalles Bibliográficos
Autores principales:	Yanamandra, Kiran, Jiang, Hong, Mahan, Thomas E, Maloney, Susan E, Wozniak, David F, Diamond, Marc I, Holtzman, David M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369277/ https://www.ncbi.nlm.nih.gov/pubmed/25815354 http://dx.doi.org/10.1002/acn3.176

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