Cargando…

Anti-tau antibody reduces insoluble tau and decreases brain atrophy

OBJECTIVE: We previously found a strong reduction in tau pathology and insoluble tau in P301S tau transgenic mice following intracerebroventricular infusion of the anti-tau antibody HJ8.5. We sought to determine the effects of HJ8.5 in the same model following peripheral administration. METHODS: The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yanamandra, Kiran, Jiang, Hong, Mahan, Thomas E, Maloney, Susan E, Wozniak, David F, Diamond, Marc I, Holtzman, David M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369277/ https://www.ncbi.nlm.nih.gov/pubmed/25815354 http://dx.doi.org/10.1002/acn3.176

Ejemplares similares

Effects of Resveratrol and Morin on Insoluble Tau in Tau Transgenic Mice
por: Yu, Kwun Chung, et al.
Publicado: (2018)

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy
por: Congdon, Erin E., et al.
Publicado: (2016)

Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers
por: Cowan, Catherine M., et al.
Publicado: (2015)

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
por: Ising, Christina, et al.
Publicado: (2017)

CHIP-mediated hyperubiquitylation of tau promotes its self-assembly into the insoluble tau filaments
por: Kim, Ji Hyeon, et al.
Publicado: (2021)

Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
por: Ising, Christina, et al.
Publicado: (2017)

A driver or a passenger? D421-caspase cleaved tau is associated with aggregated and insoluble tau
por: Gibson, Yolanda, et al.
Publicado: (2013)

Altered sleep and EEG power in the P301S Tau transgenic mouse model
por: Holth, Jerrah K., et al.
Publicado: (2017)

N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain
por: Schlegel, Kerstin, et al.
Publicado: (2019)

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti‐tau antibody AT8
por: Malia, Thomas J., et al.
Publicado: (2016)

Analysis of in vivo turnover of tau in a mouse model of tauopathy
por: Yamada, Kaoru, et al.
Publicado: (2015)

Neuronal activity regulates extracellular tau in vivo
por: Yamada, Kaoru, et al.
Publicado: (2014)

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody
por: Luo, Wenjie, et al.
Publicado: (2015)

Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)
por: Gibbons, Garrett S., et al.
Publicado: (2019)

Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration
por: Chaves, Rodrigo S., et al.
Publicado: (2016)

Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration
por: Drieu, Antoine, et al.
Publicado: (2023)

Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease
por: Llibre-Guerra, Jorge J., et al.
Publicado: (2019)

Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model
por: Manos, Justine D., et al.
Publicado: (2021)

VCP increases or decreases tau seeding using specific cofactors
por: Batra, Sushobhna, et al.
Publicado: (2023)

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau
por: Courade, Jean-Philippe, et al.
Publicado: (2018)

Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds
por: Hitt, Brian D., et al.
Publicado: (2023)

Tau and atrophy: domain-specific relationships with cognition
por: Digma, Leonardino A., et al.
Publicado: (2019)

Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice
por: Anglada‐Huguet, Marta, et al.
Publicado: (2021)

Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice
por: Vitale, Francesca, et al.
Publicado: (2018)

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau
por: Taniguchi-Watanabe, Sayuri, et al.
Publicado: (2015)

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI(2)/Tau Transgenic Mice
por: Garringer, Holly J., et al.
Publicado: (2013)

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
por: Xu, Yin, et al.
Publicado: (2021)

Tau strains shape disease
por: Vaquer-Alicea, Jaime, et al.
Publicado: (2021)

Neuronal activity enhances tau propagation and tau pathology in vivo
por: Wu, Jessica W., et al.
Publicado: (2016)

Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons
por: Hoe, Hyang-Sook, et al.
Publicado: (2006)

Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease
por: Sintini, Irene, et al.
Publicado: (2019)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

Targeting tauopathy with engineered tau-degrading intrabodies
por: Gallardo, Gilbert, et al.
Publicado: (2019)

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
por: Martini-Stoica, Heidi, et al.
Publicado: (2018)

Search for the decays $B_s^0\to\tau^+\tau^-$ and $B^0\to\tau^+\tau^-$
por: Aaij, Roel, et al.
Publicado: (2017)

Updated Measurement of the \tau Polarisation in \tau -> \tau(K)\nu_\tau
por: Moraes, D, et al.
Publicado: (1998)

Tau monomer encodes strains
por: Sharma, Apurwa M, et al.
Publicado: (2018)

Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice
por: Bajracharya, Rinie, et al.
Publicado: (2021)

Early stages of tau pathology and its associations with functional connectivity, atrophy and memory
por: Berron, David, et al.
Publicado: (2021)

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models
por: Sankaranarayanan, Sethu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_fortvvvesm0uumn3jmmp25jkcf