The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China

We investigated the prevalence of neutralizing antibodies (NA) to human Adenovirus (Ad) 5 both in healthy subjects (HS) and Chronic Hepatitis B (CHB) patients in Shanghai. Detection of anti-Ad5 NA (percentage of detection and titers) was similar between HS and CHB patients. A high percentage of subj...

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Autores principales: Huang, Dao, Hennequi, Marie, Elvachev, Alexei, Menguy, Thierry, Silvestre, Nathalie, Yu, DeMin, Han, Yue, Inchauspé, Geneviève, Zhang, Xinxin, Zhu, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2015
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369289/
https://www.ncbi.nlm.nih.gov/pubmed/25616844
http://dx.doi.org/10.1007/s00705-015-2333-2
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author Huang, Dao
Hennequi, Marie
Elvachev, Alexei
Menguy, Thierry
Silvestre, Nathalie
Yu, DeMin
Han, Yue
Inchauspé, Geneviève
Zhang, Xinxin
Zhu, Ren
author_facet Huang, Dao
Hennequi, Marie
Elvachev, Alexei
Menguy, Thierry
Silvestre, Nathalie
Yu, DeMin
Han, Yue
Inchauspé, Geneviève
Zhang, Xinxin
Zhu, Ren
author_sort Huang, Dao
collection PubMed
description We investigated the prevalence of neutralizing antibodies (NA) to human Adenovirus (Ad) 5 both in healthy subjects (HS) and Chronic Hepatitis B (CHB) patients in Shanghai. Detection of anti-Ad5 NA (percentage of detection and titers) was similar between HS and CHB patients. A high percentage of subjects harbored no detectable antibodies (32.2 %) while proportion of subjects displaying very high antibody titers was low (4 %). Neither demographic factors (gender, age, health) nor AST/ALT or HBV circulating DNA titers affected detection of Ad5-specific NA. These observations pave the ground for development of Ad5-based immunotherapeutics aiming at treating CHB patients in China.
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spelling pubmed-43692892015-03-26 The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China Huang, Dao Hennequi, Marie Elvachev, Alexei Menguy, Thierry Silvestre, Nathalie Yu, DeMin Han, Yue Inchauspé, Geneviève Zhang, Xinxin Zhu, Ren Arch Virol Brief Report We investigated the prevalence of neutralizing antibodies (NA) to human Adenovirus (Ad) 5 both in healthy subjects (HS) and Chronic Hepatitis B (CHB) patients in Shanghai. Detection of anti-Ad5 NA (percentage of detection and titers) was similar between HS and CHB patients. A high percentage of subjects harbored no detectable antibodies (32.2 %) while proportion of subjects displaying very high antibody titers was low (4 %). Neither demographic factors (gender, age, health) nor AST/ALT or HBV circulating DNA titers affected detection of Ad5-specific NA. These observations pave the ground for development of Ad5-based immunotherapeutics aiming at treating CHB patients in China. Springer Vienna 2015-01-24 2015 /pmc/articles/PMC4369289/ /pubmed/25616844 http://dx.doi.org/10.1007/s00705-015-2333-2 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Brief Report
Huang, Dao
Hennequi, Marie
Elvachev, Alexei
Menguy, Thierry
Silvestre, Nathalie
Yu, DeMin
Han, Yue
Inchauspé, Geneviève
Zhang, Xinxin
Zhu, Ren
The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China
title The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China
title_full The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China
title_fullStr The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China
title_full_unstemmed The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China
title_short The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China
title_sort sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis b carrier state in china
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369289/
https://www.ncbi.nlm.nih.gov/pubmed/25616844
http://dx.doi.org/10.1007/s00705-015-2333-2
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