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The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China
We investigated the prevalence of neutralizing antibodies (NA) to human Adenovirus (Ad) 5 both in healthy subjects (HS) and Chronic Hepatitis B (CHB) patients in Shanghai. Detection of anti-Ad5 NA (percentage of detection and titers) was similar between HS and CHB patients. A high percentage of subj...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369289/ https://www.ncbi.nlm.nih.gov/pubmed/25616844 http://dx.doi.org/10.1007/s00705-015-2333-2 |
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author | Huang, Dao Hennequi, Marie Elvachev, Alexei Menguy, Thierry Silvestre, Nathalie Yu, DeMin Han, Yue Inchauspé, Geneviève Zhang, Xinxin Zhu, Ren |
author_facet | Huang, Dao Hennequi, Marie Elvachev, Alexei Menguy, Thierry Silvestre, Nathalie Yu, DeMin Han, Yue Inchauspé, Geneviève Zhang, Xinxin Zhu, Ren |
author_sort | Huang, Dao |
collection | PubMed |
description | We investigated the prevalence of neutralizing antibodies (NA) to human Adenovirus (Ad) 5 both in healthy subjects (HS) and Chronic Hepatitis B (CHB) patients in Shanghai. Detection of anti-Ad5 NA (percentage of detection and titers) was similar between HS and CHB patients. A high percentage of subjects harbored no detectable antibodies (32.2 %) while proportion of subjects displaying very high antibody titers was low (4 %). Neither demographic factors (gender, age, health) nor AST/ALT or HBV circulating DNA titers affected detection of Ad5-specific NA. These observations pave the ground for development of Ad5-based immunotherapeutics aiming at treating CHB patients in China. |
format | Online Article Text |
id | pubmed-4369289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-43692892015-03-26 The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China Huang, Dao Hennequi, Marie Elvachev, Alexei Menguy, Thierry Silvestre, Nathalie Yu, DeMin Han, Yue Inchauspé, Geneviève Zhang, Xinxin Zhu, Ren Arch Virol Brief Report We investigated the prevalence of neutralizing antibodies (NA) to human Adenovirus (Ad) 5 both in healthy subjects (HS) and Chronic Hepatitis B (CHB) patients in Shanghai. Detection of anti-Ad5 NA (percentage of detection and titers) was similar between HS and CHB patients. A high percentage of subjects harbored no detectable antibodies (32.2 %) while proportion of subjects displaying very high antibody titers was low (4 %). Neither demographic factors (gender, age, health) nor AST/ALT or HBV circulating DNA titers affected detection of Ad5-specific NA. These observations pave the ground for development of Ad5-based immunotherapeutics aiming at treating CHB patients in China. Springer Vienna 2015-01-24 2015 /pmc/articles/PMC4369289/ /pubmed/25616844 http://dx.doi.org/10.1007/s00705-015-2333-2 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Brief Report Huang, Dao Hennequi, Marie Elvachev, Alexei Menguy, Thierry Silvestre, Nathalie Yu, DeMin Han, Yue Inchauspé, Geneviève Zhang, Xinxin Zhu, Ren The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China |
title | The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China |
title_full | The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China |
title_fullStr | The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China |
title_full_unstemmed | The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China |
title_short | The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China |
title_sort | sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis b carrier state in china |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369289/ https://www.ncbi.nlm.nih.gov/pubmed/25616844 http://dx.doi.org/10.1007/s00705-015-2333-2 |
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