Prmt5: a guardian of the germline protects future generations

Primordial germ cells (PGCs) are the embryonic precursors of the germ cell lineage that form sperm and egg cells. It is of great importance to preserve the germline from DNA damage and potentially from epimutations in order to ensure the survival of future generations. Recent research highlights the...

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Detalles Bibliográficos
Autores principales: Berrens, Rebecca V, Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Have You Seen?
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369307/
https://www.ncbi.nlm.nih.gov/pubmed/25687507
http://dx.doi.org/10.15252/embj.201591054
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author Berrens, Rebecca V
Reik, Wolf
author_facet Berrens, Rebecca V
Reik, Wolf
author_sort Berrens, Rebecca V
collection PubMed
description Primordial germ cells (PGCs) are the embryonic precursors of the germ cell lineage that form sperm and egg cells. It is of great importance to preserve the germline from DNA damage and potentially from epimutations in order to ensure the survival of future generations. Recent research highlights the role of the protein arginine methyltransferase 5 (PRMT5) as an important player in DNA protection during germline development in the mouse (Kim et al, 2014 & Li et al, 2015).
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spelling pubmed-43693072015-04-29 Prmt5: a guardian of the germline protects future generations Berrens, Rebecca V Reik, Wolf EMBO J Have You Seen? Primordial germ cells (PGCs) are the embryonic precursors of the germ cell lineage that form sperm and egg cells. It is of great importance to preserve the germline from DNA damage and potentially from epimutations in order to ensure the survival of future generations. Recent research highlights the role of the protein arginine methyltransferase 5 (PRMT5) as an important player in DNA protection during germline development in the mouse (Kim et al, 2014 & Li et al, 2015). BlackWell Publishing Ltd 2015-03-12 2015-02-16 /pmc/articles/PMC4369307/ /pubmed/25687507 http://dx.doi.org/10.15252/embj.201591054 Text en © 2015 The Authors. Published under the terms of the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Have You Seen?
Berrens, Rebecca V
Reik, Wolf
Prmt5: a guardian of the germline protects future generations
title Prmt5: a guardian of the germline protects future generations
title_full Prmt5: a guardian of the germline protects future generations
title_fullStr Prmt5: a guardian of the germline protects future generations
title_full_unstemmed Prmt5: a guardian of the germline protects future generations
title_short Prmt5: a guardian of the germline protects future generations
title_sort prmt5: a guardian of the germline protects future generations
topic Have You Seen?
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369307/
https://www.ncbi.nlm.nih.gov/pubmed/25687507
http://dx.doi.org/10.15252/embj.201591054
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