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An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents

We describe the synthesis of C8-alkynyl adenine pyranonucleosides 4, 5, and 8-phenylethynyl-adenine (II), via Sonogashira cross-coupling reaction under microwave irradiation. Compounds 4e and II were less cytostatic than 5-fluorouracil (almost an order of magnitude) against murine leukemia (L1210) a...

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Detalles Bibliográficos
Autores principales:	Dimopoulou, Athina, Manta, Stella, Parmenopoulou, Vanessa, Kollatos, Nikolaos, Christidou, Ourania, Triantakonstanti, Virginia V., Schols, Dominique, Komiotis, Dimitri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369668/ https://www.ncbi.nlm.nih.gov/pubmed/25853123 http://dx.doi.org/10.3389/fchem.2015.00021

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