Pharmacophore elucidation and molecular docking studies on phosphodiesterase-5 inhibitors

cGMP-binding cGMP-specific PDE, PDE5 plays a key role in the hydrolysis of cyclic guanidine monophosphate. Because cGMP mediates vascular functions, a PDE5 inhibitor that elevates cGMP level is an attractive means for vasodilatation and treatment of erectile dysfunction. In this paper we report the...

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Detalles Bibliográficos
Autor principal: Radwan, Awwad Abdoh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2015
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369680/
https://www.ncbi.nlm.nih.gov/pubmed/25848165
http://dx.doi.org/10.6026/97320630011063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369680/
https://www.ncbi.nlm.nih.gov/pubmed/25848165
http://dx.doi.org/10.6026/97320630011063

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