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Pharmacophore elucidation and molecular docking studies on phosphodiesterase-5 inhibitors
cGMP-binding cGMP-specific PDE, PDE5 plays a key role in the hydrolysis of cyclic guanidine monophosphate. Because cGMP mediates vascular functions, a PDE5 inhibitor that elevates cGMP level is an attractive means for vasodilatation and treatment of erectile dysfunction. In this paper we report the...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Biomedical Informatics
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369680/ https://www.ncbi.nlm.nih.gov/pubmed/25848165 http://dx.doi.org/10.6026/97320630011063 |