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Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B

Traditional Chinese Medicine (TCM) treatment has been commonly used to treat Chronic Hepatitis B (CHB) in Asian countries based on TCM syndrome diagnosis, also called “ZHENG”. The syndrome is identified through the four-diagnostic methods, with certain degree of subjectivity and ambiguity from indiv...

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Autores principales: Kang, Hong, Zhao, Yu, Li, Chao, Chen, Yujia, Tang, Kailin, Yang, Linlin, Ma, Chao, Peng, Jinghua, Zhu, Ruixin, Liu, Qi, Hu, Yiyang, Cao, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369723/
https://www.ncbi.nlm.nih.gov/pubmed/25797918
http://dx.doi.org/10.1038/srep09395
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author Kang, Hong
Zhao, Yu
Li, Chao
Chen, Yujia
Tang, Kailin
Yang, Linlin
Ma, Chao
Peng, Jinghua
Zhu, Ruixin
Liu, Qi
Hu, Yiyang
Cao, Zhiwei
author_facet Kang, Hong
Zhao, Yu
Li, Chao
Chen, Yujia
Tang, Kailin
Yang, Linlin
Ma, Chao
Peng, Jinghua
Zhu, Ruixin
Liu, Qi
Hu, Yiyang
Cao, Zhiwei
author_sort Kang, Hong
collection PubMed
description Traditional Chinese Medicine (TCM) treatment has been commonly used to treat Chronic Hepatitis B (CHB) in Asian countries based on TCM syndrome diagnosis, also called “ZHENG”. The syndrome is identified through the four-diagnostic methods, with certain degree of subjectivity and ambiguity from individual doctors. Normally those CHB patients also receive series of parameters from modern clinical examination, while they are routinely believed to be unrelated with the TCM syndrome diagnosis. In this study, we investigated whether these biomedical indexes in modern medicine could be beneficial to TCM syndrome diagnostics in an integrative way. Based on 634 patient samples from health controls and three subtypes of CHB syndromes, a two-view based hierarchical classification model was tested for TCM syndromes prediction based on totally 222 parameters integrated from both TCM practice and modern clinical tests. The results indicated that the performance of syndrome classification based on a proper integration of TCM and modern clinical indexes was significantly higher than those based on one view of parameters only. Furthermore, those indexes correlated with CHB syndrome diagnosis were successfully identified for CM indexes and biochemical indexes respectively, where potential associations between them were hinted to the MAPK signaling pathway.
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spelling pubmed-43697232015-04-06 Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B Kang, Hong Zhao, Yu Li, Chao Chen, Yujia Tang, Kailin Yang, Linlin Ma, Chao Peng, Jinghua Zhu, Ruixin Liu, Qi Hu, Yiyang Cao, Zhiwei Sci Rep Article Traditional Chinese Medicine (TCM) treatment has been commonly used to treat Chronic Hepatitis B (CHB) in Asian countries based on TCM syndrome diagnosis, also called “ZHENG”. The syndrome is identified through the four-diagnostic methods, with certain degree of subjectivity and ambiguity from individual doctors. Normally those CHB patients also receive series of parameters from modern clinical examination, while they are routinely believed to be unrelated with the TCM syndrome diagnosis. In this study, we investigated whether these biomedical indexes in modern medicine could be beneficial to TCM syndrome diagnostics in an integrative way. Based on 634 patient samples from health controls and three subtypes of CHB syndromes, a two-view based hierarchical classification model was tested for TCM syndromes prediction based on totally 222 parameters integrated from both TCM practice and modern clinical tests. The results indicated that the performance of syndrome classification based on a proper integration of TCM and modern clinical indexes was significantly higher than those based on one view of parameters only. Furthermore, those indexes correlated with CHB syndrome diagnosis were successfully identified for CM indexes and biochemical indexes respectively, where potential associations between them were hinted to the MAPK signaling pathway. Nature Publishing Group 2015-03-23 /pmc/articles/PMC4369723/ /pubmed/25797918 http://dx.doi.org/10.1038/srep09395 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Kang, Hong
Zhao, Yu
Li, Chao
Chen, Yujia
Tang, Kailin
Yang, Linlin
Ma, Chao
Peng, Jinghua
Zhu, Ruixin
Liu, Qi
Hu, Yiyang
Cao, Zhiwei
Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B
title Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B
title_full Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B
title_fullStr Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B
title_full_unstemmed Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B
title_short Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B
title_sort integrating clinical indexes into four-diagnostic information contributes to the traditional chinese medicine (tcm) syndrome diagnosis of chronic hepatitis b
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369723/
https://www.ncbi.nlm.nih.gov/pubmed/25797918
http://dx.doi.org/10.1038/srep09395
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