Developing Exposure/Response Models for Anticancer Drug Treatment: Special Considerations

Anticancer agents often have a narrow therapeutic index (TI), requiring precise dosing to ensure sufficient exposure for clinical activity while minimizing toxicity. These agents frequently have complex pharmacology, and combination therapy may cause schedule-specific effects and interactions. We re...

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Detalles Bibliográficos
Autores principales: Mould, DR, Walz, A-C, Lave, T, Gibbs, JP, Frame, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369756/
https://www.ncbi.nlm.nih.gov/pubmed/26225225
http://dx.doi.org/10.1002/psp4.16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369756/
https://www.ncbi.nlm.nih.gov/pubmed/26225225
http://dx.doi.org/10.1002/psp4.16

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