Cargando…

β-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKα signalling pathways in human lung cancer cells: the role of Sp1

β-elemene, a compound derived from Rhizoma zedoariae, is a promising new plant-derived drug with broad-spectrum anticancer activity. However, the underlying mechanism by which this agent inhibits human lung cancer cell growth has not been well elucidated. In this study, we showed that β-elemene inhi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, ShunYu, Wu, Jingjing, Zheng, Fang, Tang, Qing, Yang, LiJun, Li, Liuning, Wu, WanYin, Hann, Swei Sunny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369819/ https://www.ncbi.nlm.nih.gov/pubmed/25598321 http://dx.doi.org/10.1111/jcmm.12476

Ejemplares similares

Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPKα and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells
por: Zheng, Fang, et al.
Publicado: (2015)

Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells
por: Wu, Jingjing, et al.
Publicado: (2015)

Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to β-elemene-inhibited growth of nasopharyngeal carcinoma cells
por: Wu, JingJing, et al.
Publicado: (2017)

p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine
por: Zheng, Fang, et al.
Publicado: (2014)

Chinese Herbal Medicine Fuzheng Kang-Ai Decoction Inhibited Lung Cancer Cell Growth through AMPKα-Mediated Induction and Interplay of IGFBP1 and FOXO3a
por: Zheng, Fang, et al.
Publicado: (2016)

The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1
por: Zheng, Fang, et al.
Publicado: (2017)

The regulation and interaction of colon cancer‐associated transcript‐1 and miR7‐5p contribute to the inhibition of SP1 expression by solamargine in human nasopharyngeal carcinoma cells
por: Wu, JingJing, et al.
Publicado: (2019)

Activation of AMPKα mediates additive effects of solamargine and metformin on suppressing MUC1 expression in castration-resistant prostate cancer cells
por: Xiang, SongTao, et al.
Publicado: (2016)

Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer
por: Zheng, Fang, et al.
Publicado: (2018)

Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I
por: Li, Longmei, et al.
Publicado: (2016)

Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65
por: Hann, Swei Sunny, et al.
Publicado: (2013)

Novel reciprocal interaction of lncRNA HOTAIR and miR‐214‐3p contribute to the solamargine‐inhibited PDPK1 gene expression in human lung cancer
por: Tang, Qing, et al.
Publicado: (2019)

Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells
por: Chen, YuQing, et al.
Publicado: (2015)

Repression of phosphoinositide-dependent protein kinase 1 expression by ciglitazone via Egr-1 represents a new approach for inhibition of lung cancer cell growth
por: Hann, SWei Sunny, et al.
Publicado: (2014)

Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
por: Li, Jing, et al.
Publicado: (2015)

Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces Lung Cancer Cell Apoptosis via STAT3/Bcl-2/Caspase-3 Pathway
por: Wang, Sumei, et al.
Publicado: (2018)

Erratum to: Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells
por: Yang, LiJun, et al.
Publicado: (2016)

Targeting EP4 downstream c‐Jun through ERK1/2‐mediated reduction of DNMT1 reveals novel mechanism of solamargine‐inhibited growth of lung cancer cells
por: Chen, Yuqing, et al.
Publicado: (2016)

Traditional Chinese medicine, Fuzheng Kang-Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway
por: Li, Longmei, et al.
Publicado: (2017)

Traditional Chinese medicine, Fuzheng Kang-Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway
por: Li, Longmei, et al.
Publicado: (2021)

Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells
por: Yang, Li Jun, et al.
Publicado: (2016)

Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin
por: WU, JINGJING, et al.
Publicado: (2014)

β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway
por: Zhou, Yingyu, et al.
Publicado: (2022)

The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation
por: Ma, Li-Tian, et al.
Publicado: (2022)

Asymmetric total synthesis of (1S,2S,4S)-β-elemene
por: Chen, Wei, et al.
Publicado: (2022)

DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy
por: Wu, Ning, et al.
Publicado: (2023)

FBP1 induced by β‐elemene enhances the sensitivity of gefitinib in lung cancer
por: Li, Jian, et al.
Publicado: (2022)

Elémens de Chimie
Publicado: (1836)

Interaction Of c-Jun And HOTAIR- Increased Expression Of p21 Converge In Polyphyllin I-Inhibited Growth Of Human Lung Cancer Cells
por: Zhao, YueYang, et al.
Publicado: (2019)

Novel Tumor Suppressor lncRNA Growth Arrest-Specific 5 (GAS5) In Human Cancer
por: Yu, Yaya, et al.
Publicado: (2019)

Biological Roles and Mechanisms of Circular RNA in Human Cancers
por: Tang, Qing, et al.
Publicado: (2020)

β-elemene enhances cisplatin-induced apoptosis in bladder cancer cells through the ROS-AMPK signaling pathway
por: Gan, Daoju, et al.
Publicado: (2020)

Elemene Induces Apoptosis of Human Gastric Cancer Cell Line BGC-823 via Extracellular Signal-Regulated Kinase (ERK) 1/2 Signaling Pathway
por: Li, Pihong, et al.
Publicado: (2017)

The mechanism of m(6)A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by β-elemene
por: Liu, Shuiping, et al.
Publicado: (2020)

β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway
por: Yu, Xiaomu, et al.
Publicado: (2019)

Élemens de pathologie chirurgicale

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy
por: Zhai, Bingtao, et al.
Publicado: (2018)

Down-Regulation of Hypoxia-Inducible Factor-1α and Downstream Glucose Transporter Protein-1 Gene by β-elemene Enhancing the Radiosensitivity of Lung Adenocarcinoma Transplanted Tumor
por: Wu, Wenbo, et al.
Publicado: (2020)

The emerging roles of PIWI-interacting RNA in human cancers
por: Yu, Yaya, et al.
Publicado: (2019)

β-elemene enhances the antitumor activity of erlotinib by inducing apoptosis through AMPK and MAPK pathways in TKI-resistant H1975 lung cancer cells
por: Wang, Jue, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cbitpp856q3fti0cqvcoqpd4qa