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The Interplay between Synaptic Activity and Neuroligin Function in the CNS
Neuroligins (NLs) are postsynaptic transmembrane cell-adhesion proteins that play a key role in the regulation of excitatory and inhibitory synapses. Previous in vitro and in vivo studies have suggested that NLs contribute to synapse formation and synaptic transmission. Consistent with their localiz...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369883/ https://www.ncbi.nlm.nih.gov/pubmed/25839034 http://dx.doi.org/10.1155/2015/498957 |
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author | Hu, Xiaoge Luo, Jian-hong Xu, Junyu |
author_facet | Hu, Xiaoge Luo, Jian-hong Xu, Junyu |
author_sort | Hu, Xiaoge |
collection | PubMed |
description | Neuroligins (NLs) are postsynaptic transmembrane cell-adhesion proteins that play a key role in the regulation of excitatory and inhibitory synapses. Previous in vitro and in vivo studies have suggested that NLs contribute to synapse formation and synaptic transmission. Consistent with their localization, NL1 and NL3 selectively affect excitatory synapses, whereas NL2 specifically affects inhibitory synapses. Deletions or mutations in NL genes have been found in patients with autism spectrum disorders or mental retardations, and mice harboring the reported NL deletions or mutations exhibit autism-related behaviors and synapse dysfunction. Conversely, synaptic activity can regulate the phosphorylation, expression, and cleavage of NLs, which, in turn, can influence synaptic activity. Thus, in clinical research, identifying the relationship between NLs and synapse function is critical. In this review, we primarily discuss how NLs and synaptic activity influence each other. |
format | Online Article Text |
id | pubmed-4369883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43698832015-04-02 The Interplay between Synaptic Activity and Neuroligin Function in the CNS Hu, Xiaoge Luo, Jian-hong Xu, Junyu Biomed Res Int Review Article Neuroligins (NLs) are postsynaptic transmembrane cell-adhesion proteins that play a key role in the regulation of excitatory and inhibitory synapses. Previous in vitro and in vivo studies have suggested that NLs contribute to synapse formation and synaptic transmission. Consistent with their localization, NL1 and NL3 selectively affect excitatory synapses, whereas NL2 specifically affects inhibitory synapses. Deletions or mutations in NL genes have been found in patients with autism spectrum disorders or mental retardations, and mice harboring the reported NL deletions or mutations exhibit autism-related behaviors and synapse dysfunction. Conversely, synaptic activity can regulate the phosphorylation, expression, and cleavage of NLs, which, in turn, can influence synaptic activity. Thus, in clinical research, identifying the relationship between NLs and synapse function is critical. In this review, we primarily discuss how NLs and synaptic activity influence each other. Hindawi Publishing Corporation 2015 2015-03-09 /pmc/articles/PMC4369883/ /pubmed/25839034 http://dx.doi.org/10.1155/2015/498957 Text en Copyright © 2015 Xiaoge Hu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Hu, Xiaoge Luo, Jian-hong Xu, Junyu The Interplay between Synaptic Activity and Neuroligin Function in the CNS |
title | The Interplay between Synaptic Activity and Neuroligin Function in the CNS |
title_full | The Interplay between Synaptic Activity and Neuroligin Function in the CNS |
title_fullStr | The Interplay between Synaptic Activity and Neuroligin Function in the CNS |
title_full_unstemmed | The Interplay between Synaptic Activity and Neuroligin Function in the CNS |
title_short | The Interplay between Synaptic Activity and Neuroligin Function in the CNS |
title_sort | interplay between synaptic activity and neuroligin function in the cns |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369883/ https://www.ncbi.nlm.nih.gov/pubmed/25839034 http://dx.doi.org/10.1155/2015/498957 |
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