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Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG

Attention deficit hyperactivity disorder (ADHD) affects 5-6% of school aged children worldwide. Pharmacological therapy is considered the first-line treatment and methylphenidate (MPH) is considered the first-choice medication. There are two formulations: immediate release (IR) MPH and long-acting (...

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Autores principales: Durand-Rivera, Alfredo, Alatorre-Miguel, Efren, Zambrano-Sánchez, Elizabeth, Reyes-Legorreta, Celia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369942/
https://www.ncbi.nlm.nih.gov/pubmed/25838946
http://dx.doi.org/10.1155/2015/207801
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author Durand-Rivera, Alfredo
Alatorre-Miguel, Efren
Zambrano-Sánchez, Elizabeth
Reyes-Legorreta, Celia
author_facet Durand-Rivera, Alfredo
Alatorre-Miguel, Efren
Zambrano-Sánchez, Elizabeth
Reyes-Legorreta, Celia
author_sort Durand-Rivera, Alfredo
collection PubMed
description Attention deficit hyperactivity disorder (ADHD) affects 5-6% of school aged children worldwide. Pharmacological therapy is considered the first-line treatment and methylphenidate (MPH) is considered the first-choice medication. There are two formulations: immediate release (IR) MPH and long-acting (or extended release) formulation (MPH-ER). In this work, we measure the efficacy of treatment for both presentations in one month with Conners' scales and electroencephalography (EEG). Results. for IR group, in parents and teachers Conners test, all items showed significant differences, towards improvement, except for teachers in perfectionism and emotional instability. For ER group in parent's Conners test, the items in which there were no significant differences are psychosomatic and emotional instability. For teachers, there were no significant differences in: hyperactivity and perfectionism. Comparing the Conners questionnaires (parents versus teachers) we find significant differences before and after treatment in hyperactivity, perfectionism, psychosomatics, DSM-IV hyperactive-impulsive, and DSM-IV total. In the EEG the Wilcoxon test showed a significant difference (P < 0.0001). As we can see, both presentations are suitable for managing the ADHD and have the same effect on the symptomatology and in the EEG.
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spelling pubmed-43699422015-04-02 Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG Durand-Rivera, Alfredo Alatorre-Miguel, Efren Zambrano-Sánchez, Elizabeth Reyes-Legorreta, Celia Neurol Res Int Clinical Study Attention deficit hyperactivity disorder (ADHD) affects 5-6% of school aged children worldwide. Pharmacological therapy is considered the first-line treatment and methylphenidate (MPH) is considered the first-choice medication. There are two formulations: immediate release (IR) MPH and long-acting (or extended release) formulation (MPH-ER). In this work, we measure the efficacy of treatment for both presentations in one month with Conners' scales and electroencephalography (EEG). Results. for IR group, in parents and teachers Conners test, all items showed significant differences, towards improvement, except for teachers in perfectionism and emotional instability. For ER group in parent's Conners test, the items in which there were no significant differences are psychosomatic and emotional instability. For teachers, there were no significant differences in: hyperactivity and perfectionism. Comparing the Conners questionnaires (parents versus teachers) we find significant differences before and after treatment in hyperactivity, perfectionism, psychosomatics, DSM-IV hyperactive-impulsive, and DSM-IV total. In the EEG the Wilcoxon test showed a significant difference (P < 0.0001). As we can see, both presentations are suitable for managing the ADHD and have the same effect on the symptomatology and in the EEG. Hindawi Publishing Corporation 2015 2015-03-08 /pmc/articles/PMC4369942/ /pubmed/25838946 http://dx.doi.org/10.1155/2015/207801 Text en Copyright © 2015 Alfredo Durand-Rivera et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Durand-Rivera, Alfredo
Alatorre-Miguel, Efren
Zambrano-Sánchez, Elizabeth
Reyes-Legorreta, Celia
Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG
title Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG
title_full Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG
title_fullStr Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG
title_full_unstemmed Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG
title_short Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG
title_sort methylphenidate efficacy: immediate versus extended release at short term in mexican children with adhd assessed by conners scale and eeg
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369942/
https://www.ncbi.nlm.nih.gov/pubmed/25838946
http://dx.doi.org/10.1155/2015/207801
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