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Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population

Aim. To investigate incidental adrenal enlargement clinical characteristics and functional status and analyze functional lesion risk factors. Materials and Methods. This retrospective study included 578 patients with adrenal imaging features showing enlargement. Incidental adrenal enlargement cases...

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Autores principales: Li, Le-le, Gu, Wei-jun, Dou, Jing-tao, Yang, Guo-qing, Lv, Zhao-hui, Mu, Yi-ming, Lu, Ju-ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369954/
https://www.ncbi.nlm.nih.gov/pubmed/25838823
http://dx.doi.org/10.1155/2015/192874
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author Li, Le-le
Gu, Wei-jun
Dou, Jing-tao
Yang, Guo-qing
Lv, Zhao-hui
Mu, Yi-ming
Lu, Ju-ming
author_facet Li, Le-le
Gu, Wei-jun
Dou, Jing-tao
Yang, Guo-qing
Lv, Zhao-hui
Mu, Yi-ming
Lu, Ju-ming
author_sort Li, Le-le
collection PubMed
description Aim. To investigate incidental adrenal enlargement clinical characteristics and functional status and analyze functional lesion risk factors. Materials and Methods. This retrospective study included 578 patients with adrenal imaging features showing enlargement. Incidental adrenal enlargement cases (78) were considered eligible. Demographics, functional diagnosis, adrenal imaging features, and concomitant diseases were analyzed. Results. The number of adrenal enlargements and proportion of incidental adrenal enlargement increased each year. Mean patient age was 50.32 years. Thirty-nine cases had unilateral enlargement on the left side and 3 on the right side; 36 had bilateral enlargement. Routine medical checkup was found to have the greatest chance (43.59%) of revealing clinical onsets leading to discovery. Biochemical and functional evaluation revealed 54 (69.23%) cases of nonfunctional lesions, 12 (15.38%) of subclinical Cushing syndrome, 6 (7.69%) of primary hyperaldosteronism, 1 (1.28%) of metastasis, and 5 (6.41%) of unknown functional status. Nodular adrenal enlargement (OR, 7.306; 95% CI, 1.727–28.667; P = 0.006) was a risk factor for functional lesions. Age and lesion location were not significant factors. Conclusion. Incidental adrenal enlargement is a frequent radiographic finding and is accompanied by diverse clinical factors that require proper evaluation and management. Nodular adrenal enlargement was a risk factor.
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spelling pubmed-43699542015-04-02 Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population Li, Le-le Gu, Wei-jun Dou, Jing-tao Yang, Guo-qing Lv, Zhao-hui Mu, Yi-ming Lu, Ju-ming Int J Endocrinol Research Article Aim. To investigate incidental adrenal enlargement clinical characteristics and functional status and analyze functional lesion risk factors. Materials and Methods. This retrospective study included 578 patients with adrenal imaging features showing enlargement. Incidental adrenal enlargement cases (78) were considered eligible. Demographics, functional diagnosis, adrenal imaging features, and concomitant diseases were analyzed. Results. The number of adrenal enlargements and proportion of incidental adrenal enlargement increased each year. Mean patient age was 50.32 years. Thirty-nine cases had unilateral enlargement on the left side and 3 on the right side; 36 had bilateral enlargement. Routine medical checkup was found to have the greatest chance (43.59%) of revealing clinical onsets leading to discovery. Biochemical and functional evaluation revealed 54 (69.23%) cases of nonfunctional lesions, 12 (15.38%) of subclinical Cushing syndrome, 6 (7.69%) of primary hyperaldosteronism, 1 (1.28%) of metastasis, and 5 (6.41%) of unknown functional status. Nodular adrenal enlargement (OR, 7.306; 95% CI, 1.727–28.667; P = 0.006) was a risk factor for functional lesions. Age and lesion location were not significant factors. Conclusion. Incidental adrenal enlargement is a frequent radiographic finding and is accompanied by diverse clinical factors that require proper evaluation and management. Nodular adrenal enlargement was a risk factor. Hindawi Publishing Corporation 2015 2015-03-08 /pmc/articles/PMC4369954/ /pubmed/25838823 http://dx.doi.org/10.1155/2015/192874 Text en Copyright © 2015 Le-le Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Le-le
Gu, Wei-jun
Dou, Jing-tao
Yang, Guo-qing
Lv, Zhao-hui
Mu, Yi-ming
Lu, Ju-ming
Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population
title Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population
title_full Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population
title_fullStr Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population
title_full_unstemmed Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population
title_short Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population
title_sort incidental adrenal enlargement: an overview from a retrospective study in a chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369954/
https://www.ncbi.nlm.nih.gov/pubmed/25838823
http://dx.doi.org/10.1155/2015/192874
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