Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency

Wolf-Hirschhorn syndrome (WHS) is a rare congenital disorder occurring in approximately 1/50 000 births, with marked pre- and postnatal growth failure. WHS results from the hemizygous deletion encompassing the 4p16.3 region. This report of two children with WHS shows that growth hormone treatment in...

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Detalles Bibliográficos
Autores principales: Austin, Devon E., Gunn, Alistair J., Jefferies, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370007/
https://www.ncbi.nlm.nih.gov/pubmed/25988083
http://dx.doi.org/10.1093/omcr/omv008
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author Austin, Devon E.
Gunn, Alistair J.
Jefferies, Craig A.
author_facet Austin, Devon E.
Gunn, Alistair J.
Jefferies, Craig A.
author_sort Austin, Devon E.
collection PubMed
description Wolf-Hirschhorn syndrome (WHS) is a rare congenital disorder occurring in approximately 1/50 000 births, with marked pre- and postnatal growth failure. WHS results from the hemizygous deletion encompassing the 4p16.3 region. This report of two children with WHS shows that growth hormone treatment in selected children with WHS and severe short stature may have a substantial effect on long-term growth.
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spelling pubmed-43700072015-05-18 Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency Austin, Devon E. Gunn, Alistair J. Jefferies, Craig A. Oxf Med Case Reports Case Reports Wolf-Hirschhorn syndrome (WHS) is a rare congenital disorder occurring in approximately 1/50 000 births, with marked pre- and postnatal growth failure. WHS results from the hemizygous deletion encompassing the 4p16.3 region. This report of two children with WHS shows that growth hormone treatment in selected children with WHS and severe short stature may have a substantial effect on long-term growth. Oxford University Press 2015-02-28 /pmc/articles/PMC4370007/ /pubmed/25988083 http://dx.doi.org/10.1093/omcr/omv008 Text en © The Author 2015. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Reports
Austin, Devon E.
Gunn, Alistair J.
Jefferies, Craig A.
Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency
title Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency
title_full Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency
title_fullStr Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency
title_full_unstemmed Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency
title_short Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency
title_sort severe short stature and wolf-hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370007/
https://www.ncbi.nlm.nih.gov/pubmed/25988083
http://dx.doi.org/10.1093/omcr/omv008
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