Hyperpigmented cutaneous lesions that flare-up with scratching: Darier's sign

We present the case of a 40-year-old male with a past medical history of urticaria pigmentosa (UP) who presented for consultation to the Allergy clinic for an opinion of systemic mastocytosis. Previous workups included elevated serum tryptase level, UP on skin biopsy and an increased number of CD117...

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Autores principales: Cuervo-Pardo, Lyda B., Gonzalez-Estrada, Alexei, Ruiz, Sory J., Pien, Lily C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370013/
https://www.ncbi.nlm.nih.gov/pubmed/25988075
http://dx.doi.org/10.1093/omcr/omv004
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author Cuervo-Pardo, Lyda B.
Gonzalez-Estrada, Alexei
Ruiz, Sory J.
Pien, Lily C.
author_facet Cuervo-Pardo, Lyda B.
Gonzalez-Estrada, Alexei
Ruiz, Sory J.
Pien, Lily C.
author_sort Cuervo-Pardo, Lyda B.
collection PubMed
description We present the case of a 40-year-old male with a past medical history of urticaria pigmentosa (UP) who presented for consultation to the Allergy clinic for an opinion of systemic mastocytosis. Previous workups included elevated serum tryptase level, UP on skin biopsy and an increased number of CD117-positive/CD25-positive mast cells on bone marrow biopsy. This case emphasizes the importance of physical findings such as Darier's sign in patients with hyperpigmented lesions, which virtually supports the diagnosis UP, raises the suspicion for systemic mastocytosis and guides further diagnostic evaluation. This case also outlines the management of systemic mastocytosis.
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spelling pubmed-43700132015-05-18 Hyperpigmented cutaneous lesions that flare-up with scratching: Darier's sign Cuervo-Pardo, Lyda B. Gonzalez-Estrada, Alexei Ruiz, Sory J. Pien, Lily C. Oxf Med Case Reports Case Reports We present the case of a 40-year-old male with a past medical history of urticaria pigmentosa (UP) who presented for consultation to the Allergy clinic for an opinion of systemic mastocytosis. Previous workups included elevated serum tryptase level, UP on skin biopsy and an increased number of CD117-positive/CD25-positive mast cells on bone marrow biopsy. This case emphasizes the importance of physical findings such as Darier's sign in patients with hyperpigmented lesions, which virtually supports the diagnosis UP, raises the suspicion for systemic mastocytosis and guides further diagnostic evaluation. This case also outlines the management of systemic mastocytosis. Oxford University Press 2015-02-16 /pmc/articles/PMC4370013/ /pubmed/25988075 http://dx.doi.org/10.1093/omcr/omv004 Text en © The Author 2015. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Reports
Cuervo-Pardo, Lyda B.
Gonzalez-Estrada, Alexei
Ruiz, Sory J.
Pien, Lily C.
Hyperpigmented cutaneous lesions that flare-up with scratching: Darier's sign
title Hyperpigmented cutaneous lesions that flare-up with scratching: Darier's sign
title_full Hyperpigmented cutaneous lesions that flare-up with scratching: Darier's sign
title_fullStr Hyperpigmented cutaneous lesions that flare-up with scratching: Darier's sign
title_full_unstemmed Hyperpigmented cutaneous lesions that flare-up with scratching: Darier's sign
title_short Hyperpigmented cutaneous lesions that flare-up with scratching: Darier's sign
title_sort hyperpigmented cutaneous lesions that flare-up with scratching: darier's sign
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370013/
https://www.ncbi.nlm.nih.gov/pubmed/25988075
http://dx.doi.org/10.1093/omcr/omv004
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