Cargando…

siRNA suppression of hTERT using activatable cell-penetrating peptides in hepatoma cells

Activatable cell-penetrating peptides (aCPPs) allow non-viral, low cytotoxic and selective delivery of compounds into target cells for cancer therapy. In tumour cells, up-regulation of human telomerase reverse transcriptase (hTERT) frequently occurs and is being considered as a target in cancer diag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hua, He, Jiwen, Yi, Huimin, Xiang, Guoan, Chen, Kaiyun, Fu, Binsheng, Yang, Yang, Chen, Guihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370094/ https://www.ncbi.nlm.nih.gov/pubmed/25671640 http://dx.doi.org/10.1042/BSR20140145

Ejemplares similares

Enhancing siRNA-based cancer therapy using a new pH-responsive activatable cell-penetrating peptide-modified liposomal system
por: Xiang, Bai, et al.
Publicado: (2017)

Versatility of cell-penetrating peptides for intracellular delivery of siRNA
por: Singh, Tejinder, et al.
Publicado: (2018)

Activatable cell-penetrating peptides: 15 years of research
por: de Jong, Heleen, et al.
Publicado: (2020)

The intrabody targeting of hTERT attenuates the immortality of cancer cells
por: Zhu, Xiangying, et al.
Publicado: (2009)

Peptide-Ligand Binding Modeling of siRNA with Cell-Penetrating Peptides
por: García-Sosa, Alfonso T., et al.
Publicado: (2014)

A retro-inverso cell-penetrating peptide for siRNA delivery
por: Vaissière, Anaïs, et al.
Publicado: (2017)

Primary and hTERT-Transduced Mesothelioma-Associated Fibroblasts but Not Primary or hTERT-Transduced Mesothelial Cells Stimulate Growth of Human Mesothelioma Cells
por: Ries, Alexander, et al.
Publicado: (2023)

A photoresponsive antibody–siRNA conjugate for activatable immunogene therapy of cancer
por: Wang, Xingxing, et al.
Publicado: (2022)

In Vivo Targeting of Hydrogen Peroxide by Activatable Cell-Penetrating Peptides
por: Weinstain, Roy, et al.
Publicado: (2013)

Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001
por: Inderberg-Suso, Else-Marit, et al.
Publicado: (2012)

A Novel Long Non-Coding RNA in the hTERT Promoter Region Regulates hTERT Expression
por: Malhotra, Sanandan, et al.
Publicado: (2017)

Ablation effects of noninvasive radiofrequency field-induced hyperthermia on liver cancer cells
por: Chen, Kaiyun, et al.
Publicado: (2016)

Antithetic hTERT Regulation by Androgens in Prostate Cancer Cells: hTERT Inhibition Is Mediated by the ING1 and ING2 Tumor Suppressors
por: Bartsch, Sophie, et al.
Publicado: (2021)

hTERT DNA Methylation Analysis Identifies a Biomarker for Retinoic Acid-Induced hTERT Repression in Breast Cancer Cell Lines
por: Nguyen, Eric, et al.
Publicado: (2022)

Exploring hTERT promoter methylation in cutaneous T‐cell lymphomas
por: Chebly, Alain, et al.
Publicado: (2021)

Spotlight on hTERT Complex Regulation in Cutaneous T-Cell Lymphomas
por: Ropio, Joana, et al.
Publicado: (2023)

The Codelivery of siRNA and QDs by pH-Responsive Micelle for Hepatoma Cancer Cells
por: Cao, Zhonglin, et al.
Publicado: (2019)

The tetrapeptide core of the carrier peptide Xentry is cell-penetrating: novel activatable forms of Xentry
por: Montrose, Kristopher, et al.
Publicado: (2014)

An Improved Model for the hTERT Promoter Quadruplex
por: Chaires, Jonathan B., et al.
Publicado: (2014)

Effects of hTERT transfection on the telomere and telomerase of Periplaneta americana cells in vitro
por: Ma, Chenjing, et al.
Publicado: (2023)

Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer
por: Yang, Ruozhu, et al.
Publicado: (2023)

Trends in the Binding of Cell Penetrating Peptides to siRNA: A Molecular Docking Study
por: Rathnayake, P. V. G. M., et al.
Publicado: (2017)

Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery
por: Tuttolomondo, Martina, et al.
Publicado: (2017)

hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
por: Suso, Else M. Inderberg, et al.
Publicado: (2011)

Proteome alteration induced by hTERT transfection of human fibroblast cells
por: Mazzucchelli, Gabriel D, et al.
Publicado: (2008)

Functional and gene expression analysis of hTERT overexpressed endothelial cells
por: Takano, Haruna, et al.
Publicado: (2008)

hTERT promotes cell adhesion and migration independent of telomerase activity
por: Liu, Haiying, et al.
Publicado: (2016)

hTERT deficiency in naïve T cells affects lymphocyte homeostasis in myelodysplastic syndrome patients
por: Yang, Lili, et al.
Publicado: (2013)

Tuning of Peptide Cytotoxicity with Cell Penetrating Motif Activatable by Matrix Metalloproteinase-2
por: Lee, Jeonghun, et al.
Publicado: (2022)

ShRNA-mediated silencing of hTERT promote apoptosis and senescence in human ovarian cancer cells
por: Su, Chen, et al.
Publicado: (2019)

Telomere length and hTERT in mania and subsequent remission
por: Çinar, Rugül Köse
Publicado: (2017)

Establishing and characterizing human stem cells from the apical papilla immortalized by hTERT gene transfer
por: Cheng, Qianyu, et al.
Publicado: (2023)

Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions
por: Ezzat, Kariem, et al.
Publicado: (2012)

Cell-Penetrating Peptide and siRNA-Mediated Therapeutic Effects on Endometriosis and Cancer In Vitro Models
por: Kiisholts, Kristina, et al.
Publicado: (2021)

Oleyl Conjugated Histidine-Arginine Cell-Penetrating Peptides as Promising Agents for siRNA Delivery
por: Sajid, Muhammad Imran, et al.
Publicado: (2022)

Regulation of hTERT by BCR-ABL at multiple levels in K562 cells
por: Chai, Juin Hsien, et al.
Publicado: (2011)

hTERT promoter activity identifies osteosarcoma cells with increased EMT characteristics
por: YU, LING, et al.
Publicado: (2014)

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity
por: Yu, Ling, et al.
Publicado: (2013)

Downregulation of hTERT contributes to ovarian cancer apoptosis and inhibits proliferation of ovarian cancer cells
por: Wang, Qing-An-Zi, et al.
Publicado: (2020)

NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer
por: Feng, Xu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_o0ij3pbu24ee60r3i78f05aek6