Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit

Dabigatran is a direct thrombin inhibitor indicated for thromboembolism prophylaxis in patients with non-valvular atrial fibrillation. The procedure to manage dabigatran-associated haemorrhages is not well formalized. Conventional haemodialysis has been evaluated with good results. Patients with dab...

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Autores principales: Claisse, Guillaume, Delavenne, Xavier, Masson, Ingrid, Maillard, Nicolas, Alamartine, Eric, Mariat, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Contents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370301/
https://www.ncbi.nlm.nih.gov/pubmed/25815177
http://dx.doi.org/10.1093/ckj/sfv001
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author Claisse, Guillaume
Delavenne, Xavier
Masson, Ingrid
Maillard, Nicolas
Alamartine, Eric
Mariat, Christophe
author_facet Claisse, Guillaume
Delavenne, Xavier
Masson, Ingrid
Maillard, Nicolas
Alamartine, Eric
Mariat, Christophe
author_sort Claisse, Guillaume
collection PubMed
description Dabigatran is a direct thrombin inhibitor indicated for thromboembolism prophylaxis in patients with non-valvular atrial fibrillation. The procedure to manage dabigatran-associated haemorrhages is not well formalized. Conventional haemodialysis has been evaluated with good results. Patients with dabigatran-associated bleeding may be unstable and convective techniques like venovenous haemodiafiltration (HDF) can be interesting. We report the case of a 74-year-old, critically ill patient with haemorrhagic shock and dabigatran overexposure due to acute kidney injury. He underwent HDF and dabigatran blood concentrations decreased from 325.3 ng/mL to 160.5 ng/mL. We report here key pharmacokinetics parameters (half-life, extraction coefficient, clearance).
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spelling pubmed-43703012015-03-26 Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit Claisse, Guillaume Delavenne, Xavier Masson, Ingrid Maillard, Nicolas Alamartine, Eric Mariat, Christophe Clin Kidney J Contents Dabigatran is a direct thrombin inhibitor indicated for thromboembolism prophylaxis in patients with non-valvular atrial fibrillation. The procedure to manage dabigatran-associated haemorrhages is not well formalized. Conventional haemodialysis has been evaluated with good results. Patients with dabigatran-associated bleeding may be unstable and convective techniques like venovenous haemodiafiltration (HDF) can be interesting. We report the case of a 74-year-old, critically ill patient with haemorrhagic shock and dabigatran overexposure due to acute kidney injury. He underwent HDF and dabigatran blood concentrations decreased from 325.3 ng/mL to 160.5 ng/mL. We report here key pharmacokinetics parameters (half-life, extraction coefficient, clearance). Oxford University Press 2015-04 2015-01-24 /pmc/articles/PMC4370301/ /pubmed/25815177 http://dx.doi.org/10.1093/ckj/sfv001 Text en © The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Contents
Claisse, Guillaume
Delavenne, Xavier
Masson, Ingrid
Maillard, Nicolas
Alamartine, Eric
Mariat, Christophe
Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit
title Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit
title_full Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit
title_fullStr Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit
title_full_unstemmed Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit
title_short Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit
title_sort venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit
topic Contents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370301/
https://www.ncbi.nlm.nih.gov/pubmed/25815177
http://dx.doi.org/10.1093/ckj/sfv001
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