Cargando…

P2Y12 expression and function in alternatively activated human microglia

OBJECTIVE: To investigate and measure the functional significance of altered P2Y12 expression in the context of human microglia activation. METHODS: We performed in vitro and in situ experiments to measure how P2Y12 expression can influence disease-relevant functional properties of classically activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moore, Craig S., Ase, Ariel R., Kinsara, Angham, Rao, Vijayaraghava T.S., Michell-Robinson, Mackenzie, Leong, Soo Yuen, Butovsky, Oleg, Ludwin, Samuel K., Séguéla, Philippe, Bar-Or, Amit, Antel, Jack P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370387/ https://www.ncbi.nlm.nih.gov/pubmed/25821842 http://dx.doi.org/10.1212/NXI.0000000000000080

Ejemplares similares

Sequencing the immunopathologic heterogeneity in multiple sclerosis
por: Antel, Jack P, et al.
Publicado: (2015)

Heterogeneity of oligodendrocyte progenitor cells in adult human brain
por: Leong, Soo Yuen, et al.
Publicado: (2014)

Cross-talk between B cells, microglia and macrophages, and implications to central nervous system compartmentalized inflammation and progressive multiple sclerosis
por: Touil, Hanane, et al.
Publicado: (2023)

An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels
por: Ase, Ariel R., et al.
Publicado: (2019)

Post-translational regulation of P2X receptor channels: modulation by phospholipids
por: Bernier, Louis-Philippe, et al.
Publicado: (2013)

Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
por: Wu, Celina, et al.
Publicado: (2013)

Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
por: Zrzavy, Tobias, et al.
Publicado: (2017)

The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis
por: Cox, Laura M., et al.
Publicado: (2022)

Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosis
por: Michell‐Robinson, Mackenzie A., et al.
Publicado: (2015)

Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia
por: Butovsky, Oleg, et al.
Publicado: (2013)

Retinal microglia initiate neuroinflammation in ocular autoimmunity
por: Okunuki, Yoko, et al.
Publicado: (2019)

The Ca(V)2α1 EF-hand F helix tyrosine, a highly conserved locus for GPCR inhibition of Ca(V)2 channels
por: Dunn, Tyler W., et al.
Publicado: (2018)

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes
por: Dodiya, Hemraj B., et al.
Publicado: (2019)

Pro‐inflammatory activation of microglia in the brain of patients with sepsis
por: Zrzavy, T., et al.
Publicado: (2018)

Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors
por: Alkhani, Hazim, et al.
Publicado: (2014)

Effects of Biotin on survival, ensheathment, and ATP production by oligodendrocyte lineage cells in vitro
por: Cui, Qiao-Ling, et al.
Publicado: (2020)

The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
por: West, Phillip K., et al.
Publicado: (2022)

Acute microglia ablation induces neurodegeneration in the somatosensory system
por: Rubino, Stephen J., et al.
Publicado: (2018)

Optogenetic Silencing of Na(v)1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain123
por: Daou, Ihab, et al.
Publicado: (2016)

Complement 3(+)-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
por: Hartmann, Kristin, et al.
Publicado: (2019)

Erratum: microRNA dysregulation in multiple sclerosis
por: Moore, Craig S., et al.
Publicado: (2013)

Dark microglia: A new phenotype predominantly associated with pathological states
por: Bisht, Kanchan, et al.
Publicado: (2016)

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment
por: Okunuki, Yoko, et al.
Publicado: (2018)

Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions
por: Rao, Vijayaraghava T. S., et al.
Publicado: (2017)

Distinct microglia alternative splicing in Alzheimer's disease
por: Lu, Yanjun, et al.
Publicado: (2022)

MicroRNA dysregulation in multiple sclerosis
por: Jr, Omar de Faria, et al.
Publicado: (2013)

Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors
por: Mo, Gary, et al.
Publicado: (2009)

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
por: Lund, Harald, et al.
Publicado: (2018)

Selective proliferative response of microglia to alternative polarization signals
por: Pepe, Giovanna, et al.
Publicado: (2017)

Potential Benefit of the Charge-Stabilized Nanostructure Saline RNS60 for Myelin Maintenance and Repair
por: Rao, Vijayaraghava T. S., et al.
Publicado: (2016)

POLR3-Related Leukodystrophy: Exploring Potential Therapeutic Approaches
por: Perrier, Stefanie, et al.
Publicado: (2021)

Chronic lithium treatment alters the excitatory/inhibitory balance of synaptic networks and reduces mGluR5–PKC signalling in mouse cortical neurons
por: Khayachi, Anouar, et al.
Publicado: (2021)

Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder
por: Guneykaya, Dilansu, et al.
Publicado: (2023)

Excess Circulating Alternatively Activated Myeloid (M2) Cells Accelerate ALS Progression While Inhibiting Experimental Autoimmune Encephalomyelitis
por: Vaknin, Ilan, et al.
Publicado: (2011)

Decreased RNA polymerase III subunit expression leads to defects in oligodendrocyte development
por: Macintosh, Julia, et al.
Publicado: (2023)

Oligodendrocyte Precursor Cell Transplantation into Organotypic Cerebellar Shiverer Slices: A Model to Study Myelination and Myelin Maintenance
por: Bin, Jenea M., et al.
Publicado: (2012)

Differential roles of microglia and monocytes in the inflamed central nervous system
por: Yamasaki, Ryo, et al.
Publicado: (2014)

Editorial: Microglia in neuroinflammation
por: Ayata, Pinar, et al.
Publicado: (2023)

Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain
por: Xu, Zhen, et al.
Publicado: (2021)

Comparison of the ESHRE–ESGE and ASRM classifications of Müllerian duct anomalies in everyday practice
por: Ludwin, A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_iue2778j0ichj3e7jakbnnrtss