Cargando…

Inhibition of Zn(II) Binding Type IA Topoisomerases by Organomercury Compounds and Hg(II)

Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement. Many antibacterial and anticancer drugs act as topoisome...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Bokun, Annamalai, Thirunavukkarasu, Sandhaus, Shayna, Bansod, Priyanka, Tse-Dinh, Yuk-Ching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370478/ https://www.ncbi.nlm.nih.gov/pubmed/25798600 http://dx.doi.org/10.1371/journal.pone.0120022

Ejemplares similares

Type IA Topoisomerases as Targets for Infectious Disease Treatments
por: Seddek, Ahmed, et al.
Publicado: (2021)

Analysis of DNA relaxation and cleavage activities of recombinant Mycobacterium tuberculosis DNA topoisomerase I from a new expression and purification protocol
por: Annamalai, Thirunavukkarasu, et al.
Publicado: (2009)

The interaction between transport-segment DNA and topoisomerase IA—crystal structure of MtbTOP1 in complex with both G- and T-segments
por: Ferdous, Shomita, et al.
Publicado: (2022)

Mechanism of Type IA Topoisomerases
por: Dasgupta, Tumpa, et al.
Publicado: (2020)

Discovery of novel bacterial topoisomerase I inhibitors by use of in silico docking and in vitro assays
por: Sandhaus, Shayna, et al.
Publicado: (2018)

The role of the Zn(II) binding domain in the mechanism of E. coli DNA topoisomerase I
por: Ahumada, Adriana, et al.
Publicado: (2002)

Direct Observation of Topoisomerase IA Gate Dynamics
por: Mills, Maria, et al.
Publicado: (2018)

Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor
por: Cheng, Bokun, et al.
Publicado: (2013)

Dinuclear Hg(II) tetracarbene complex-triggered aggregation-induced emission for rapid and selective sensing of Hg(2+) and organomercury species
por: Yuan, Bin, et al.
Publicado: (2019)

Microheterogeneity of Topoisomerase IA/IB and Their DNA-Bound States
por: Jeanne Dit Fouque, Kevin, et al.
Publicado: (2019)

Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site
por: Cao, Nan, et al.
Publicado: (2018)

Microbial Type IA Topoisomerase C-Terminal Domain Sequence Motifs, Distribution and Combination
por: Diaz, Brenda, et al.
Publicado: (2022)

Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains
por: Cao, Nan, et al.
Publicado: (2020)

Bacterial topoisomerase I as a target for discovery of antibacterial compounds
por: Tse-Dinh, Yuk-Ching
Publicado: (2009)

Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I
por: Cheng, Bokun, et al.
Publicado: (2008)

Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I
por: Tan, Kemin, et al.
Publicado: (2015)

Localization of Mycobacterium tuberculosis topoisomerase I C-terminal sequence motif required for inhibition by endogenous toxin MazF4
por: Garcia, Pamela K., et al.
Publicado: (2022)

Experimental and computational investigations of Ser10 and Lys13 in the binding and cleavage of DNA substrates by Escherichia coli DNA topoisomerase I
por: Strahs, Daniel, et al.
Publicado: (2006)

Antifungal Activity of Solventlessly Synthesized Organomercurials
por: Kidwai, M., et al.
Publicado: (2002)

The DNA relaxation activity and covalent complex accumulation of Mycobacterium tuberculosis topoisomerase I can be assayed in Escherichia coli: application for identification of potential FRET-dye labeling sites
por: Narula, Gagandeep, et al.
Publicado: (2010)

Inhibition of Mg(2+) binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region
por: Sorokin, Elena P., et al.
Publicado: (2008)

Microextraction Techniques Used in the Procedures for Determining Organomercury and Organotin Compounds in Environmental Samples
por: Rutkowska, Małgorzata, et al.
Publicado: (2014)

Organomercury Nucleic Acids: Past, Present and Future
por: Ukale, Dattatraya, et al.
Publicado: (2021)

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases
por: Schmidt, Bryan H., et al.
Publicado: (2010)

Evidence on Neurotoxicity after Intrauterine and Childhood Exposure to Organomercurials
por: Azevedo, Lara Ferreira, et al.
Publicado: (2023)

Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage
por: Narula, Gagandeep, et al.
Publicado: (2012)

Deacetylation of topoisomerase I is an important physiological function of E. coli CobB
por: Zhou, Qingxuan, et al.
Publicado: (2017)

Thermal Studies of Zn(II), Cd(II) and Hg(II) Complexes of Some N-Alkyl-N-Phenyl-Dithiocarbamates
por: Onwudiwe, Damian C., et al.
Publicado: (2012)

Mechanistic pathways of mercury removal from the organomercurial lyase active site
por: Silva, Pedro J., et al.
Publicado: (2015)

Resistance to topoisomerase cleavage complex induced lethality in Escherichia coli via titration of transcription regulators PurR and FNR
por: Liu, I-Fen, et al.
Publicado: (2011)

Self-Assembly by Tridentate or Bidentate Ligand: Synthesis and Vapor Adsorption Properties of Cu(II), Zn(II), Hg(II) and Cd(II) Complexes Derived from a Bis(pyridylhydrazone) Compound
por: Liu, Hong-Juan, et al.
Publicado: (2020)

Biochemical Basis of E. coli Topoisomerase I Relaxation Activity Reduction by Nonenzymatic Lysine Acetylation
por: Zhou, Qingxuan, et al.
Publicado: (2018)

A diverse global fungal library for drug discovery
por: Niu, Guodong, et al.
Publicado: (2020)

Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching
por: Wang, Yunke, et al.
Publicado: (2019)

Some Heteroaromatic Organomercurials, Their Syntheses and Reactions: A Review of Our Research (1980-2000)
por: Skulski, Lech, et al.
Publicado: (2001)

Marine-Derived Compounds Targeting Topoisomerase II in Cancer Cells: A Review
por: Greco, Giulia, et al.
Publicado: (2022)

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint
por: Kozuki, Toshiyuki, et al.
Publicado: (2017)

Hyperthermia, thermotolerance and topoisomerase II inhibitors.
por: Kampinga, H. H.
Publicado: (1995)

Localization of topoisomerase II in mitotic chromosomes
Publicado: (1985)

Topoisomerase II has to work late
por: Leslie, Mitch
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ktclia59l7t4gpv19nuga161iu