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Influence of the Expression Level of O(6)-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass Spectrometry

Chloroethylnitrosoureas (CENUs), which are bifunctional alkylating agents widely used in the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a guanine-cytosine DNA base pair. However, the formation of dG-dC crosslinks can be prevented by O(6)-alkylguanine-DNA alk...

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Detalles Bibliográficos
Autores principales:	Li, Lili, Li, Sisi, Sun, Guohui, Peng, Ruizeng, Zhao, Lijiao, Zhong, Rugang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370500/ https://www.ncbi.nlm.nih.gov/pubmed/25799182 http://dx.doi.org/10.1371/journal.pone.0121225

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