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Mitotic UV Irradiation Induces a DNA Replication-Licensing Defect that Potentiates G1 Arrest Response

Cdt1 begins to accumulate in M phase and has a key role in establishing replication licensing at the end of mitosis or in early G1 phase. Treatments that damage the DNA of cells, such as UV irradiation, induce Cdt1 degradation through PCNA-dependent CRL4-Cdt2 ubiquitin ligase. How Cdt1 degradation i...

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Detalles Bibliográficos
Autores principales:	Morino, Masayuki, Nukina, Kohei, Sakaguchi, Hiroki, Maeda, Takeshi, Takahara, Michiyo, Shiomi, Yasushi, Nishitani, Hideo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370595/ https://www.ncbi.nlm.nih.gov/pubmed/25798850 http://dx.doi.org/10.1371/journal.pone.0120553

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